Wu3857: /* Reference */

2019-08-19T23:17:46Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|TUBA1A, Alpha-tubulin 1|[https://www.uniprot.org/uniprot/P02550 P02550]|Sus scrofa|Cys213|[http://pfam.xfam.org..."

2019-07-30T19:59:57Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|TUBA1A, Alpha-tubulin 1|[https://www.uniprot.org/uniprot/P02550 P02550]|Sus scrofa|Cys213|[http://pfam.xfam.org..."

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{{#invoke:InfoboxforTarget|run|TUBA1A, Alpha-tubulin 1|[https://www.uniprot.org/uniprot/P02550 P02550]|Sus scrofa|Cys213|[http://pfam.xfam.org/family/PF00091 Tubulin family]|[[:Category:Tubulin alpha-1A chain (Sus scrofa)|Ligand list]]|Structural protein}}
==Summary==

===Protein Function ===
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (From Uniprot) 
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of α and β tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the α, β and γ tubulin families are found in all eukaryotes. The α and β tubulins represent the major components of microtubules, while γ tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple α and β tubulin genes, which are highly conserved among species. (From Wikipedia) 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (From Uniprot)
 

===Cys Function & Property===
Cys213 is close to the GTP binding site and the dimer interface. 

* Hydrophobic property:
:[[File:502-hydro.png||600px]]
* SASA：
:Cys213: 0.818 A^2

==Protein Sequence==

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN 
TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA 
NNYARGHYTI GKEIIDLVLD RIRKLADQCT GLQGFSVFHS FGGGTGSGFT 
SLLMERLSVD YGKKSKLEFS IYPAPQVSTA VVEPYNSILT THTTLEHSDC 
AFMVDNEAIY DI'''C'''RRNLDIE RPTYTNLNRL IGQIVSSITA SLRFDGALNV 
DLTEFQTNLV PYPRAHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG 
FKVGINYEPP TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA 
KRAFVHWYVG EGMEEGEFSE AREDMAALEK DYEEVGVDSV EGEGEEEGEE 
Y 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
[[File:502-2.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04145 Phagosome] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04530 Tight junction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04540 Gap junction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05130 Pathogenic Escherichia coli infection] 

==Experimental Evidence==
:DTNB Method, Immunocytochemical Staining

==Reference==
# Ishiguro K, Ando T, Watanabe O, et al. '''Specific reaction of α, β-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage[J].''' FEBS letters, 2008, 582(23-24): 3531-3536. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18805415 18805415] 

[[Category:Targets|Targets]]
[[Category:Sus scrofa|Sus scrofa]]
[[Category:Structural protein|Structural protein]]
[[Category:Tubulin family|Tubulin family]]
[[Category:Phagosome|Phagosome]]
[[Category:Apoptosis|Apoptosis]]
[[Category:Tight junction|Tight junction]]
[[Category:Gap junction|Gap junction]]
[[Category:Pathogenic Escherichia coli infection|Pathogenic Escherichia coli infection]]

@@ Line 53: / Line 53: @@
 # Ishiguro K, Ando T, Watanabe O, et al. '''Specific reaction of α, β-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage[J].''' FEBS letters, 2008, 582(23-24): 3531-3536. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18805415 18805415]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Sus scrofa|Sus scrofa]]
+[[Category:Sus scrofa]]
-[[Category:Structural protein|Structural protein]]
+[[Category:Structural protein]]
-[[Category:Tubulin family|Tubulin family]]
+[[Category:Tubulin family]]
-[[Category:Phagosome|Phagosome]]
+[[Category:Phagosome]]
-[[Category:Apoptosis|Apoptosis]]
+[[Category:Apoptosis]]
-[[Category:Tight junction|Tight junction]]
+[[Category:Tight junction]]
-[[Category:Gap junction|Gap junction]]
+[[Category:Gap junction]]
-[[Category:Pathogenic Escherichia coli infection|Pathogenic Escherichia coli infection]]
+[[Category:Pathogenic Escherichia coli infection]]

Tubulin alpha-1A chain (Sus scrofa) - Revision history

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|TUBA1A, Alpha-tubulin 1|[https://www.uniprot.org/uniprot/P02550 P02550]|Sus scrofa|Cys213|[http://pfam.xfam.org..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|TUBA1A, Alpha-tubulin 1|[https://www.uniprot.org/uniprot/P02550 P02550]|Sus scrofa|Cys213|[http://pfam.xfam.org..."