Wu3857: /* Reference */

2019-08-19T23:16:36Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Trx, TRDX, TXN|[https://www.uniprot.org/uniprot/P10599 P10599]|Homo sapiens|Cys32, Cys35|[http://pfam.xfam.org/..."

2019-08-04T01:47:38Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Trx, TRDX, TXN|[https://www.uniprot.org/uniprot/P10599 P10599]|Homo sapiens|Cys32, Cys35|[http://pfam.xfam.org/..."

New page

{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|Trx, TRDX, TXN|[https://www.uniprot.org/uniprot/P10599 P10599]|Homo sapiens|Cys32, Cys35|[http://pfam.xfam.org/family/PF00085 Thioredoxin family]|[[:Category:Thioredoxin|Ligand list]]|Redox protein}}
==Summary==

===Protein Function ===
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin plays a central role in humans and is increasingly linked to medicine through their response to reactive oxygen species (ROS). (From Wikipedia) 

===Cys Function & Property===
Cys32 and Cys35 are quite close to the active site of Trx, which could form disulfide bond or free state under differrent situtation. 

* Hydrophobic property:
:[[File:526-hydro.png||600px]]
* SASA：
:Cys32: 7.575 A^2
:Cys35: 4.701 A^2

==Protein Sequence==

MVKQIESKTA FQEALDAAGD KLVVVDFSAT W'''C'''GP'''C'''KMIKP FFHSLSEKYS 
NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT 
INELV 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
[[File:526.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04621 NOD-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05418 Fluid shear stress and atherosclerosis] 

==Experimental Evidence==
:MS/MS spectra, Tryptic Digest, Cys-directed Mutation

==Reference==
# Bradshaw T D, Matthews C S, Cookson J, et al. '''Elucidation of thioredoxin as a molecular target for antitumor quinols[J].''' Cancer research, 2005, 65(9): 3911-3919. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23441730 23441730] 15867391
# Ji W, Yang M, Praggastis A, et al. '''Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death[J].''' PloS one, 2014, 9(7): e103224. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23441730 23441730] 25068797

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Redox protein|Redox protein]]
[[Category:Thioredoxin family|Thioredoxin family]]
[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
[[Category:Fluid shear stress and atherosclerosis|Fluid shear stress and atherosclerosis]]

@@ Line 40: / Line 40: @@
 ==Reference==
 # Bradshaw T D, Matthews C S, Cookson J, et al. '''Elucidation of thioredoxin as a molecular target for antitumor quinols[J].''' Cancer research, 2005, 65(9): 3911-3919. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23441730 23441730]<br/>15867391
-# Ji W, Yang M, Praggastis A, et al. '''Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death[J].''' PloS one, 2014, 9(7): e103224. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23441730 23441730]<br/>25068797
+# Ji W, Yang M, Praggastis A, et al. '''Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death[J].''' PloS one, 2014, 9(7): e103224. [https://www.ncbi.nlm.nih.gov/pubmed/?term=25068797 25068797]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Redox protein|Redox protein]]
+[[Category:Redox protein]]
-[[Category:Thioredoxin family|Thioredoxin family]]
+[[Category:Thioredoxin family]]
-[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
+[[Category:NOD-like receptor signaling pathway]]
-[[Category:Fluid shear stress and atherosclerosis|Fluid shear stress and atherosclerosis]]
+[[Category:Fluid shear stress and atherosclerosis]]

Thioredoxin - Revision history

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Trx, TRDX, TXN|[https://www.uniprot.org/uniprot/P10599 P10599]|Homo sapiens|Cys32, Cys35|[http://pfam.xfam.org/..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Trx, TRDX, TXN|[https://www.uniprot.org/uniprot/P10599 P10599]|Homo sapiens|Cys32, Cys35|[http://pfam.xfam.org/..."