Solute carrier family 22 member 5 - Revision history

Wu3857: /* Reference */

2019-08-19T23:15:53Z

‎Reference

Wu3857: /* Related Pathway */

2019-08-19T23:15:39Z

‎Related Pathway

Wu3857: /* Related Pathway */

2019-08-19T23:15:30Z

‎Related Pathway

Wu3857 at 20:48, 29 July 2019

2019-07-29T20:48:53Z

Wu3857: /* Protein Function */

2019-07-29T03:45:10Z

‎Protein Function

Wu3857: /* Reference */

2019-07-29T03:43:44Z

‎Reference

Wu3857: /* Cys Function & Property */

2019-07-29T03:43:18Z

‎Cys Function & Property

Wu3857 at 03:42, 29 July 2019

2019-07-29T03:42:15Z

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81, Cys113, Cys13..."

2019-07-29T03:41:48Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81, Cys113, Cys13..."

New page

{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81, Cys113, Cys136|[http://pfam.xfam.org/family/PF00083 Sugar (and other) transporter], Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family|[[:Category:Solute carrier family 22 member 5|Ligand list]]}}
==Summary==

===Protein Function ===
This protein is a sodium-ion dependent, high affinity carnitine transporter, which involved in the active cellular uptake of carnitine. It could transport one sodium ion with one molecule of carnitine, and also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. (From Uniprot)
 

===Cys Function & Property===
These Cysteines are located on the extracellular domain, as shown below. 
[[File:495-function.png|center|600px]]

* Hydrophobic property:
:[[File:495-hydro.png||600px]]
* SASA：
:Unknown 

==Protein Sequence==

MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFNGMSIV FLAGTPEHR'''C''' 
LVPHTVNLSS AWRNHSIPLE TKDGRQVPQS '''C'''RRYRLATIA NFSALGLEPG 
RDVDLEQLEQ EN'''C'''LDGWEYN KDVFLSTIVT EWDLV'''C'''KDDW KAPLTTSLFF 
VGVLMGSFIS GQLSDRFGRK NVLFLTMGMQ TGFSFLQLFS VNFEMFTVLF 
VLVGMGQISN YVAAFVLGTE ILSKSIRIIF ATLGVCIFYA FGFMVLPLFA 
YFIRDWRMLL LALTVPGVLC GALWWFIPES PRWLISQGRV KEAEVIIRKA 
AKFNGIVAPS TIFDPSELQD LNSKKPQSHH IYDLVRTRNI RIITIMSIIL 
WLTISVGYFG LSLDTPNLHG DIYVNCFLLA AVEVPAYVLA WLLLQHLPRR 
YSISAALFLG GSVLLFIQLV PSELFYLSTA LVMVGKFGIT SAYSMVYVYT 
AELYPTVVRN MGVGVSSTAS RLGSILSPYF VYLGAYDRFL PYILMGSLTI 
LTAILTLFFP ESFGAPLPDT IDQMLRVKGI KQWQIQSQTR TQKDGGESPT 
VLKSTAF 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
:Unknown 

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?rno05231 Choline metabolism in cancer]
 

==Experimental Evidence==
:Crystallography, Homologous Analysis of Sequence

==Reference==
# Pochini L, Scalise M, Indiveri C. '''Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes[J].''' Chemico-biological interactions, 2009, 179(2-3): 394-401. [https://www.ncbi.nlm.nih.gov/pubmed/?term=19041296 19041296] 
# Pochini L, Peta V, Indiveri C. '''Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity[J].''' Toxicology mechanisms and methods, 2013, 23(2): 68-76. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22900493 22900493] 

[[Category:Targets|Targets]]
[[Category:Rattus norvegicus|Rattus norvegicus]]
[[Category:Major facilitator (TC 2.A.1) superfamily|Major facilitator (TC 2.A.1) superfamily]]
[[Category:Organic cation transporter (TC 2.A.1.19) family|Organic cation transporter (TC 2.A.1.19) family]]
[[Catgory:Sugar (and other) transporter|Sugar (and other) transporter]]
[[Category:Choline metabolism in cancer|Choline metabolism in cancer]]

@@ Line 51: / Line 51: @@
 # Pochini L, Peta V, Indiveri C. '''Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity[J].''' Toxicology mechanisms and methods, 2013, 23(2): 68-76. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22900493 22900493]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Rattus norvegicus|Rattus norvegicus]]
+[[Category:Rattus norvegicus]]
-[[Category:Transporter|Transporter]]
+[[Category:Transporter]]
-[[Category:Major facilitator (TC 2.A.1) superfamily|Major facilitator (TC 2.A.1) superfamily]]
+[[Category:Major facilitator (TC 2.A.1) superfamily]]
-[[Category:Organic cation transporter (TC 2.A.1.19) family|Organic cation transporter (TC 2.A.1.19) family]]
+[[Category:Organic cation transporter (TC 2.A.1.19) family]]
-[[Category:Sugar (and other) transporter|Sugar (and other) transporter]]
+[[Category:Sugar (and other) transporter]]
-[[Category:Choline metabolism in cancer|Choline metabolism in cancer]]
+[[Category:Choline metabolism in cancer]]

@@ Line 42: / Line 42: @@
 ==Related Pathway==
-*[https://www.genome.jp/kegg-bin/show_pathway?rno05231 Choline metabolism in cancer]<br/>
+*[https://www.genome.jp/kegg-bin/show_pathway?ko05231 Choline metabolism in cancer]<br/>
 ==Experimental Evidence==

@@ Line 10: / Line 10: @@
 ===Cys Function & Property===
-These Cysteines are located on the extracellular domain, as shown below.<br/>
+These cysteines are located on the extracellular domain, as shown below.<br/>
 [[File:495-function.png|center|600px]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81, Cys113, Cys136|[http://pfam.xfam.org/family/PF00083 Sugar (and other) transporter],<br/>Major facilitator (TC 2.A.1) superfamily,<br/> Organic cation transporter (TC 2.A.1.19) family|[[:Category:Solute carrier family 22 member 5|Ligand list]]}}
+{{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81,<br/>Cys113, Cys136|[http://pfam.xfam.org/family/PF00083 Sugar (and other) transporter],<br/>Major facilitator (TC 2.A.1) superfamily,<br/> Organic cation transporter (TC 2.A.1.19) family|[[:Category:Solute carrier family 22 member 5|Ligand list]]}}
 ==Summary==

@@ Line 6: / Line 6: @@
 ===Protein Function ===
-This protein is a sodium-ion dependent, high affinity carnitine transporter, which involved in the active cellular uptake of carnitine. It could transport one sodium ion with one molecule of carnitine, and also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. (From Uniprot)
+This protein is a sodium-ion dependent, high affinity carnitine transporter, which involved in the active cellular uptake of carnitine. It could transport one sodium ion with one molecule of carnitine, and also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. (From Uniprot)
 <br/>

Solute carrier family 22 member 5 - Revision history

Wu3857: /* Reference */

Wu3857: /* Related Pathway */

Wu3857: /* Related Pathway */

Wu3857 at 20:48, 29 July 2019

Wu3857: /* Protein Function */

Wu3857: /* Reference */

Wu3857: /* Cys Function & Property */

Wu3857 at 03:42, 29 July 2019

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81, Cys113, Cys13..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81, Cys113, Cys13..."