Serum albumin - Revision history

Wu3857 at 01:54, 2 December 2019

2019-12-02T01:54:23Z

Wu3857: /* Reference */

2019-12-01T04:29:06Z

‎Reference

Wu3857 at 04:26, 1 December 2019

2019-12-01T04:26:46Z

Wu3857 at 04:16, 1 December 2019

2019-12-01T04:16:00Z

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|ALB, HAS|[https://www.uniprot.org/uniprot/P02768 P02768]|Homo sapiens|Cys58|ALB/AFP/VDB family|:Category:Seru..."

2019-12-01T04:15:06Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|ALB, HAS|[https://www.uniprot.org/uniprot/P02768 P02768]|Homo sapiens|Cys58|ALB/AFP/VDB family|:Category:Seru..."

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{| align="left"
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{{#invoke:InfoboxforTarget|run|ALB, HAS|[https://www.uniprot.org/uniprot/P02768 P02768]|Homo sapiens|Cys58|ALB/AFP/VDB family|[[:Category:Serum albumin|Ligand list]]}}
==Summary==

===Protein Function ===
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. (From Uniprot) 
Serum albumin is produced by the liver, occurs dissolved in blood plasma and is the most abundant blood protein in mammals. Albumin is essential for maintaining the oncotic pressure needed for proper distribution of body fluids between blood vessels and body tissues. It functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones in the blood and plays a major role in stabilizing extracellular fluid volume by contributing to oncotic pressure (known also as colloid osmotic pressure) of plasma. (From Wikipedia) 

===Cys Function & Property===
Cys58 is close to the active sites of ALB, which is consisted by Tyr108, His63, and Asp62. 

* Hydrophobic property:
:[[File:587-hydro.png||600px]]
* SASA：
:Cys58: 8.879 A^2

==Protein Sequence==

MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA 
FAQYLQQG'''C'''PF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT 
VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA 
FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA 
CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA 
EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK 
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF 
LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE 
FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV 
SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC 
CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ 
TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV 
AASQAALGL 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
[[File:587.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04918 Thyroid hormone synthesis] 

==Experimental Evidence==
:LC-ESI-MS/MS, MALDI-TOF-TOF-MS, Tryptic Digest, 2D 1H−1H NMR TOCSY

==Reference==
#Antunes A M M, Godinho A L A, Martins I L, et al. '''Protein adducts as prospective biomarkers of nevirapine toxicity[J].''' Chemical research in toxicology, 2010, 23(11): 1714-1725.[https://www.ncbi.nlm.nih.gov/pubmed/?term=20809596 20809596] 
#Jagadish B, Guntle G P, Zhao D, et al. '''Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J].''' Journal of medicinal chemistry, 2012, 55(23): 10378-10386.[https://www.ncbi.nlm.nih.gov/pubmed/?term=23148501 23148501] 

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:ALB/AFP/VDB family]]
[[Category:Thyroid hormone synthesis]]

@@ Line 49: / Line 49: @@
 ==Reference==
-#Antunes A M M, Godinho A L A, Martins I L, et al. '''Protein adducts as prospective biomarkers of nevirapine toxicity[J].''' Chemical research in toxicology, 2010, 23(11): 1714-1725.[https://www.ncbi.nlm.nih.gov/pubmed/?term=20809596 20809596]<br/>
+#Antunes A M M, Godinho A L A, Martins I L, et al. '''Protein adducts as prospective biomarkers of nevirapine toxicity[J].''' Chemical research in toxicology, 2010, 23(11): 1714-1725. [https://www.ncbi.nlm.nih.gov/pubmed/?term=20809596 20809596]<br/>
-#Jagadish B, Guntle G P, Zhao D, et al. '''Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J].''' Journal of medicinal chemistry, 2012, 55(23): 10378-10386.[https://www.ncbi.nlm.nih.gov/pubmed/?term=23148501 23148501]<br/>
+#Jagadish B, Guntle G P, Zhao D, et al. '''Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J].''' Journal of medicinal chemistry, 2012, 55(23): 10378-10386. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23148501 23148501]<br/>