Wu3857: /* Reference */

2019-08-19T23:14:19Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|SENP2|[https://www.uniprot.org/uniprot/Q9HC62 Q9HC62]|Homo sapiens|Cys548|[http://pfam.xfam.org/family/PF02902..."

2019-08-19T21:17:53Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|SENP2|[https://www.uniprot.org/uniprot/Q9HC62 Q9HC62]|Homo sapiens|Cys548|[http://pfam.xfam.org/family/PF02902..."

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{{#invoke:InfoboxforTarget|run|SENP2|[https://www.uniprot.org/uniprot/Q9HC62 Q9HC62]|Homo sapiens|Cys548|[http://pfam.xfam.org/family/PF02902 Peptidase C48 family]|[[:Category:Sentrin-specific protease 2|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Sentrin-specific protease 2 (SENP2) is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. (From Wikipedia) 
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. (From Uniprot) 

===Cys Function & Property===
Cys548 is one of the active sites of SENP1. 

* Hydrophobic property:
:[[File:577-hydro.png||600px]]
* SASA:
:Cys548: 2.987 A^2 

==Protein Sequence==

MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP 
RLDCFIHQVK NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS 
NSSSCELTGS GSWNNMLKLG NKSPNGISDY PKIRVTVTRD QPRRVLPSFG 
FTLNSEGCNR RPGGRRHSKG NPESSLMWKP QEQAVTEMIS EESGKGLRRP 
HCTVEEGVQK EEREKYRKLL ERLKESGHGN SVCPVTSNYH SSQRSQMDTL 
KTKGWGEEQN HGVKTTQFVP KQYRLVETRG PLCSLRSEKR CSKGKITDTE 
TMVGIRFENE SRRGYQLEPD LSEEVSARLR LGSGSNGLLR RKVSIIETKE 
KNCSGKERDR RTDDLLELTE DMEKEISNAL GHGPQDEILS SAFKLRITRG 
DIQTLKNYHW LNDEVINFYM NLLVERNKKQ GYPALHVFST FFYPKLKSGG 
YQAVKRWTKG VNLFEQEIIL VPIHRKVHWS LVVIDLRKKC LKYLDSMGQK 
GHRICEILLQ YLQDESKTKR NSDLNLLEWT HHSMKPHEIP QQLNGSD'''C'''GM 
FTCKYADYIS RDKPITFTQH QMPLFRKKMV WEILHQQLL 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:[[File:577.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko03013 RNA transport] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04310 Wnt signaling pathway] 

==Experimental Evidence==
:Molecular Docking, Homologous Analysis of Sequence

==Reference==
# Ponder E L, Albrow V E, Leader B A, et al. '''Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors[J].''' Chemistry & biology, 2011, 18(6): 711-721. [https://www.ncbi.nlm.nih.gov/pubmed/?term=21700207 21700207] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Protease|Protease]]
[[Category:Peptidase C48 family|Peptidase C48 family]]
[[Category:NR3 subfamily|NR3 subfamily]]
[[Category:RNA transport|RNA transport]]
[[Category:Wnt signaling pathway|Wnt signaling pathway]]

@@ Line 50: / Line 50: @@
 # Ponder E L, Albrow V E, Leader B A, et al. '''Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors[J].''' Chemistry & biology, 2011, 18(6): 711-721. [https://www.ncbi.nlm.nih.gov/pubmed/?term=21700207 21700207]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Protease|Protease]]
+[[Category:Protease]]
-[[Category:Peptidase C48 family|Peptidase C48 family]]
+[[Category:Peptidase C48 family]]
-[[Category:NR3 subfamily|NR3 subfamily]]
+[[Category:NR3 subfamily]]
-[[Category:RNA transport|RNA transport]]
+[[Category:RNA transport]]
-[[Category:Wnt signaling pathway|Wnt signaling pathway]]
+[[Category:Wnt signaling pathway]]

Sentrin-specific protease 2 - Revision history

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|SENP2|[https://www.uniprot.org/uniprot/Q9HC62 Q9HC62]|Homo sapiens|Cys548|[http://pfam.xfam.org/family/PF02902..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|SENP2|[https://www.uniprot.org/uniprot/Q9HC62 Q9HC62]|Homo sapiens|Cys548|[http://pfam.xfam.org/family/PF02902..."