Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 - Revision history

Wu3857 at 04:16, 25 August 2019

2019-08-25T04:16:57Z

Wu3857: /* Reference */

2019-08-19T23:13:45Z

‎Reference

Wu3857 at 04:17, 3 August 2019

2019-08-03T04:17:23Z

Wu3857: /* Summary */

2019-08-03T04:13:49Z

‎Summary

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2|[https://www.uniprot.org/uniprot/P16615 P16615]|Homo sapiens|Cys674|..."

2019-08-03T04:11:03Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2|[https://www.uniprot.org/uniprot/P16615 P16615]|Homo sapiens|Cys674|..."

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{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2|[https://www.uniprot.org/uniprot/P16615 P16615]|Homo sapiens|Cys674|Cation transport ATPase (P-type) family, Type IIA subfamily|[[:Category:Sarcoplasmic/endoplasmic reticulum calcium ATPase 2|Ligand list]]|ATPase/GTPase}}
==Summary==

===Protein Function ===
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. (From Uniprot) 
SERCA Ca(2+)-ATPase is a intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. (From Wikipedia)
 

===Cys Function & Property===
Cys674 is very close to the ATP binding site in sequence. 

* Hydrophobic property:
:[[File:522-hydro.png||600px]]
* SASA：
:Cys674: Unknown

==Protein Sequence==

MENAHTKTVE EVLGHFGVNE STGLSLEQVK KLKERWGSNE LPAEEGKTLL 
ELVIEQFEDL LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILVA 
NAIVGVWQER NAENAIEALK EYEPEMGKVY RQDRKSVQRI KAKDIVPGDI 
VEIAVGDKVP ADIRLTSIKS TTLRVDQSIL TGESVSVIKH TDPVPDPRAV 
NQDKKNMLFS GTNIAAGKAM GVVVATGVNT EIGKIRDEMV ATEQERTPLQ 
QKLDEFGEQL SKVISLICIA VWIINIGHFN DPVHGGSWIR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS 
DKTGTLTTNQ MSVCRMFILD RVEGDTCSLN EFTITGSTYA PIGEVHKDDK 
PVNCHQYDGL VELATICALC NDSALDYNEA KGVYEKVGEA TETALTCLVE 
KMNVFDTELK GLSKIERANA CNSVIKQLMK KEFTLEFSRD RKSMSVYCTP 
NKPSRTSMSK MFVKGAPEGV IDRCTHIRVG STKVPMTSGV KQKIMSVIRE 
WGSGSDTLRC LALATHDNPL RREEMHLEDS ANFIKYETNL TFVGCVGMLD 
PPRIEVASSV KLCRQAGIRV IMITGDNKGT AVAICRRIGI FGQDEDVTSK 
AFTGREFDEL NPSAQRDACL NAR'''C'''FARVEP SHKSKIVEFL QSFDEITAMT 
GDGVNDAPAL KKAEIGIAMG SGTAVAKTAS EMVLADDNFS TIVAAVEEGR 
AIYNNMKQFI RYLISSNVGE VVCIFLTAAL GFPEALIPVQ LLWVNLVTDG 
LPATALGFNP PDLDIMNKPP RNPKEPLISG WLFFRYLAIG CYVGAATVGA 
AAWWFIAADG GPRVSFYQLS HFLQCKEDNP DFEGVDCAIF ESPYPMTMAL 
SVLVTIEMCN ALNSLSENQS LLRMPPWENI WLVGSICLSM SLHFLILYVE 
PLPLIFQITP LNVTQWLMVL KISLPVILMD ETLKFVARNY LEPGKECVQP 
ATKSCSFSAC TDGISWPFVL LIMPLVIWVY STDTNFSDMF WS 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
:Unknown 

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04020 Calcium signaling patshway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04022 cGMP-PKG signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04024 cAMP signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04260 Cardiac muscle contraction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04261 Adrenergic signaling in cardiomyocytes] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04919 Thyroid hormone signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04972 Pancreatic secretion] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05010 Alzheimer disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05410 Hypertrophic cardiomyopathy (HCM)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05414 Dilated cardiomyopathy (DCM)] 

==Experimental Evidence==
:Cys-directed Mutation, Cys Modifiaction Assay

==Reference==
# Lancel S, Zhang J, Evangelista A, et al. '''Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674[J].''' Circulation research, 2009, 104(6): 720-723. [https://www.ncbi.nlm.nih.gov/pubmed/?term=19265039 19265039] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Cation transport ATPase (P-type) family|Cation transport ATPase (P-type) family]]
[[Category:ATPase/GTPase|ATPase/GTPase]]
[[Category:Calcium signaling pathway|Calcium signaling pathway]]
[[Category:cGMP-PKG signaling pathway|cGMP-PKG signaling pathway]]
[[Category:cAMP signaling pathway|cAMP signaling pathway]]
[[Category:Cardiac muscle contraction|Cardiac muscle contraction]]
[[Category:Adrenergic signaling in cardiomyocytes|Adrenergic signaling in cardiomyocytes]]
[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
[[Category:Pancreatic secretion|Pancreatic secretion]]
[[Category:Alzheimer disease|Alzheimer disease]]
[[Category:Hypertrophic cardiomyopathy (HCM)|Hypertrophic cardiomyopathy (HCM)]]
[[Category:Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)]]
[[Category:Dilated cardiomyopathy (DCM)|Dilated cardiomyopathy (DCM)]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|SERCA2, SR Ca<sup>2+</sup>-ATPase 2, Calcium pump 2|[https://www.uniprot.org/uniprot/P16615 P16615]|Homo sapiens|Cys674|Cation transport ATPase (P-type) family, Type IIA subfamily|[[:Category:Sarcoplasmic/endoplasmic reticulum calcium ATPase 2|Ligand list]]|ATPase/GTPase}}
+{{#invoke:InfoboxforTarget|run|SERCA2, SR Ca<sup>2+</sup>-ATPase 2, Calcium pump 2|[https://www.uniprot.org/uniprot/P16615 P16615]|Homo sapiens|Cys674|Cation transport ATPase (P-type) family, Type IIA subfamily|[[:Category:Sarcoplasmic/endoplasmic reticulum calcium ATPase 2|Ligand list]]|Ion channel}}
 ==Summary==
@@ Line 71: / Line 71: @@
 [[Category:Homo sapiens]]
 [[Category:Cation transport ATPase (P-type) family]]
-[[Category:ATPase/GTPase]]
+[[Category:Type IIA subfamily]]
 [[Category:Calcium signaling pathway]]
 [[Category:cGMP-PKG signaling pathway]]

@@ Line 68: / Line 68: @@
 # Lancel S, Zhang J, Evangelista A, et al. '''Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674[J].''' Circulation research, 2009, 104(6): 720-723. [https://www.ncbi.nlm.nih.gov/pubmed/?term=19265039 19265039]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Cation transport ATPase (P-type) family|Cation transport ATPase (P-type) family]]
+[[Category:Cation transport ATPase (P-type) family]]
-[[Category:ATPase/GTPase|ATPase/GTPase]]
+[[Category:ATPase/GTPase]]
-[[Category:Calcium signaling pathway|Calcium signaling pathway]]
+[[Category:Calcium signaling pathway]]
-[[Category:cGMP-PKG signaling pathway|cGMP-PKG signaling pathway]]
+[[Category:cGMP-PKG signaling pathway]]
-[[Category:cAMP signaling pathway|cAMP signaling pathway]]
+[[Category:cAMP signaling pathway]]
-[[Category:Cardiac muscle contraction|Cardiac muscle contraction]]
+[[Category:Cardiac muscle contraction]]
-[[Category:Adrenergic signaling in cardiomyocytes|Adrenergic signaling in cardiomyocytes]]
+[[Category:Adrenergic signaling in cardiomyocytes]]
-[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
+[[Category:Thyroid hormone signaling pathway]]
-[[Category:Pancreatic secretion|Pancreatic secretion]]
+[[Category:Pancreatic secretion]]
-[[Category:Alzheimer disease|Alzheimer disease]]
+[[Category:Alzheimer disease]]
-[[Category:Hypertrophic cardiomyopathy (HCM)|Hypertrophic cardiomyopathy (HCM)]]
+[[Category:Hypertrophic cardiomyopathy (HCM)]]
-[[Category:Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)]]
+[[Category:Arrhythmogenic right ventricular cardiomyopathy (ARVC)]]
-[[Category:Dilated cardiomyopathy (DCM)|Dilated cardiomyopathy (DCM)]]
+[[Category:Dilated cardiomyopathy (DCM)]]