Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 - Revision history

Wu3857 at 04:14, 25 August 2019

2019-08-25T04:14:55Z

Wu3857: /* Reference */

2019-08-19T23:13:29Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation trans..."

2019-08-04T00:57:09Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation trans..."

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{| align="left"
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{{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation transport ATPase (P-type) family, Type IIA subfamily|[[:Category:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1|Ligand list]]|ATPase/GTPase}}
==Summary==

===Protein Function ===
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (From Uniprot). 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. 
SERCA Ca(2+)-ATPase is a intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. (From Wikipedia)
 

===Cys Function & Property===
Cys674 is very close to the ATP binding site in sequence. 

* Hydrophobic property:
:[[File:523-hydro.png||600px]]
* SASA：
:Cys674: Unknown

==Protein Sequence==

MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW 
ELVIEQFEDL LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA 
NAIVGVWQER NAENAIEALK EYEPEMGKVY RADRKSVQRI KARDIVPGDI 
VEVAVGDKVP ADIRILAIKS TTLRVDQSIL TGESVSVIKH TEPVPDPRAV 
NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA ATEQDKTPLQ 
QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS 
DKTGTLTTNQ MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK 
PVRPGQYDGL VELATICALC NDSSLDFNEA KGVYEKVGEA TETALTTLVE 
KMNVFNTDVR SLSKVERANA CNSVIRQLMK KEFTLEFSRD RKSMSVYCSP 
AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP VKEKIMAVIK 
EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD 
RAYTGREFDD LPLAEQREAC RRA'''C'''CFARVE PSHKSKIVEY LQSYDEITAM 
TGDGVNDAPA LKKAEIGIAM GSGTAVAKTA SEMVLADDNF STIVAAVEEG 
RAIYNNMKQF IRYLISSNVG EVVCIFLTAA LGLPEALIPV QLLWVNLVTD 
GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI GGYVGAATVG 
AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV 
DPLPMIFKLR ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEDPEDERR 
K 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
:Unknown 

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04020 Calcium signaling patshway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04022 cGMP-PKG signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04024 cAMP signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04260 Cardiac muscle contraction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04261 Adrenergic signaling in cardiomyocytes] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04919 Thyroid hormone signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04972 Pancreatic secretion] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05010 Alzheimer disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05410 Hypertrophic cardiomyopathy (HCM)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05414 Dilated cardiomyopathy (DCM)] 

==Experimental Evidence==
:Cys-directed Mutation, Cys Modifiaction Assay

==Reference==
# Lytton J, Westlin M, Hanley M R. '''Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps[J].''' Journal of Biological Chemistry, 1991, 266(26): 17067-17071. [https://www.ncbi.nlm.nih.gov/pubmed/?term=1832668 1832668] 
# Duplan V, Serba C, Garcia J, et al. '''Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway[J].''' Organic & biomolecular chemistry, 2014, 12(2): 370-375. [https://www.ncbi.nlm.nih.gov/pubmed/?term=24263232 24263232] 
# Lancel S, Zhang J, Evangelista A, et al. '''Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674[J].''' Circulation research, 2009, 104(6): 720-723. [https://www.ncbi.nlm.nih.gov/pubmed/?term=19265039 19265039] 
# Ying J, Tong X Y, Pimentel D R, et al. '''Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide[J].''' Arteriosclerosis, thrombosis, and vascular biology, 2007, 27(4): 783-790. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17234728 17234728] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Cation transport ATPase (P-type) family|Cation transport ATPase (P-type) family]]
[[Category:ATPase/GTPase|ATPase/GTPase]]
[[Category:Calcium signaling pathway|Calcium signaling pathway]]
[[Category:cGMP-PKG signaling pathway|cGMP-PKG signaling pathway]]
[[Category:cAMP signaling pathway|cAMP signaling pathway]]
[[Category:Cardiac muscle contraction|Cardiac muscle contraction]]
[[Category:Adrenergic signaling in cardiomyocytes|Adrenergic signaling in cardiomyocytes]]
[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
[[Category:Pancreatic secretion|Pancreatic secretion]]
[[Category:Alzheimer disease|Alzheimer disease]]
[[Category:Hypertrophic cardiomyopathy (HCM)|Hypertrophic cardiomyopathy (HCM)]]
[[Category:Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)]]
[[Category:Dilated cardiomyopathy (DCM)|Dilated cardiomyopathy (DCM)]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation transport ATPase (P-type) family, Type IIA subfamily|[[:Category:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1|Ligand list]]|ATPase/GTPase}}
+{{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation transport ATPase (P-type) family, Type IIA subfamily|[[:Category:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1|Ligand list]]|Ion channel}}
 ==Summary==
@@ Line 75: / Line 75: @@
 [[Category:Targets]]
 [[Category:Homo sapiens]]
 [[Category:Cation transport ATPase (P-type) family]]
-[[Category:ATPase/GTPase]]
+[[Category:Type IIA subfamily]]
 [[Category:Calcium signaling pathway]]
 [[Category:cGMP-PKG signaling pathway]]

@@ Line 73: / Line 73: @@
 # Ying J, Tong X Y, Pimentel D R, et al. '''Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide[J].''' Arteriosclerosis, thrombosis, and vascular biology, 2007, 27(4): 783-790. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17234728 17234728]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Cation transport ATPase (P-type) family|Cation transport ATPase (P-type) family]]
+[[Category:Cation transport ATPase (P-type) family]]
-[[Category:ATPase/GTPase|ATPase/GTPase]]
+[[Category:ATPase/GTPase]]
-[[Category:Calcium signaling pathway|Calcium signaling pathway]]
+[[Category:Calcium signaling pathway]]
-[[Category:cGMP-PKG signaling pathway|cGMP-PKG signaling pathway]]
+[[Category:cGMP-PKG signaling pathway]]
-[[Category:cAMP signaling pathway|cAMP signaling pathway]]
+[[Category:cAMP signaling pathway]]
-[[Category:Cardiac muscle contraction|Cardiac muscle contraction]]
+[[Category:Cardiac muscle contraction]]
-[[Category:Adrenergic signaling in cardiomyocytes|Adrenergic signaling in cardiomyocytes]]
+[[Category:Adrenergic signaling in cardiomyocytes]]
-[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
+[[Category:Thyroid hormone signaling pathway]]
-[[Category:Pancreatic secretion|Pancreatic secretion]]
+[[Category:Pancreatic secretion]]
-[[Category:Alzheimer disease|Alzheimer disease]]
+[[Category:Alzheimer disease]]
-[[Category:Hypertrophic cardiomyopathy (HCM)|Hypertrophic cardiomyopathy (HCM)]]
+[[Category:Hypertrophic cardiomyopathy (HCM)]]
-[[Category:Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)]]
+[[Category:Arrhythmogenic right ventricular cardiomyopathy (ARVC)]]
-[[Category:Dilated cardiomyopathy (DCM)|Dilated cardiomyopathy (DCM)]]
+[[Category:Dilated cardiomyopathy (DCM)]]

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 - Revision history

Wu3857 at 04:14, 25 August 2019

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation trans..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|ATP2A1, SERCA1, Calcium pump 1|[https://www.uniprot.org/uniprot/O14983 O14983]|Homo sapiens|Cys674|Cation trans..."