Pro-cathepsin H - Revision history

Wu3857: /* Reference */

2019-08-19T23:11:13Z

‎Reference

Wu3857 at 20:48, 29 July 2019

2019-07-29T20:48:03Z

Wu3857: /* Reference */

2019-07-28T20:27:05Z

‎Reference

Wu3857: /* Related Pathway */

2019-07-28T20:26:49Z

‎Related Pathway

Wu3857: /* Reference */

2019-07-28T20:25:35Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 P..."

2019-07-28T19:08:41Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 P..."

New page

{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Pro-cathepsin H|Ligand list]]}}
==Summary==

===Protein Function ===
Cathepsin H is a lysosomal cysteine proteinase, belongs to the peptidase C1 protein family. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The protein can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. (From Wikipedia) 
Important for the overall degradation of proteins in lysosomes. Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase. (From Uniprot)
 

===Cys Function & Property===
Cys141 is one of the active sites of Cathepsin H, which is very close to His281 and Asn301 in space. These three residues formed a typical catalytic triad motif. 

* Hydrophobic property:
:[[File:489-hydro.png||600px]]
* SASA：
:Cys141: 1.32 A^2

==Protein Sequence==

MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE 
YHHRLQTFAS NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ 
NCSATKSNYL RGTGPYPPSV DWRKKGNFVS PVKNQGACGS '''C'''WTFSTTGAL 
ESAIAIATGK MLSLAEQQLV DCAQDFNNHG CQGGLPSQAF EYILYNKGIM 
GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV EAVALYNPVS 
FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK 
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
[[File:489.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] 

==Experimental Evidence==
:Homologous Analysis of Sequence, Enzymatic Assay

==Reference==
# Štern I, Schaschke N, Moroder L, et al. '''Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft[J].''' Biochemical Journal, 2004, 381(2): 511-517. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15084146 15084146] 

[[Category:Targets|Targets]]
[[Category:Peptidase C1 family|Peptidase C1 family]]
[[Category:Lysosome|Lysosome]]

@@ Line 46: / Line 46: @@
 # Štern I, Schaschke N, Moroder L, et al. '''Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft[J].''' Biochemical Journal, 2004, 381(2): 511-517. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15084146 15084146]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Protease|Protease]]
+[[Category:Protease]]
-[[Category:Peptidase C1 family|Peptidase C1 family]]
+[[Category:Peptidase C1 family]]
-[[Category:Lysosome|Lysosome]]
+[[Category:Lysosome]]
-[[Category:Apoptosis|Apoptosis]]
+[[Category:Apoptosis]]

← Older revision		Revision as of 20:27, 28 July 2019
Line 50:		Line 50:
	[[Category:Peptidase C1 family\|Peptidase C1 family]]		[[Category:Peptidase C1 family\|Peptidase C1 family]]
	[[Category:Lysosome\|Lysosome]]		[[Category:Lysosome\|Lysosome]]
		+	[[Category:Apoptosis\|Apoptosis]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Pro-cathepsin H|Ligand list]]}}
+{{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Pro-cathepsin H|Ligand list]]|Protease}}
 ==Summary==
@@ Line 48: / Line 48: @@
 [[Category:Targets|Targets]]
 [[Category:Homo sapiens|Homo sapiens]]
 [[Category:Peptidase C1 family|Peptidase C1 family]]
 [[Category:Lysosome|Lysosome]]
 [[Category:Apoptosis|Apoptosis]]

@@ Line 38: / Line 38: @@
 ==Related Pathway==
 *[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] <br/>
 ==Experimental Evidence==

Pro-cathepsin H - Revision history

Wu3857: /* Reference */

Wu3857 at 20:48, 29 July 2019

Wu3857: /* Reference */

Wu3857: /* Related Pathway */

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 P..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 P..."