NF-kappa-B p65 (Homo sapiens) - Revision history

Wu3857: /* Reference */

2019-08-19T23:08:34Z

‎Reference

Wu3857: /* Related Pathway */

2019-08-01T03:03:52Z

‎Related Pathway

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|NFKB3, Rela, Transcription factor p65|[https://www.uniprot.org/uniprot/Q04206 Q04206]|Homo sapiens|Cys38|[http:..."

2019-08-01T03:02:07Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|NFKB3, Rela, Transcription factor p65|[https://www.uniprot.org/uniprot/Q04206 Q04206]|Homo sapiens|Cys38|[http:..."

New page

{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|NFKB3, Rela, Transcription factor p65|[https://www.uniprot.org/uniprot/Q04206 Q04206]|Homo sapiens|Cys38|[http://pfam.xfam.org/family/PF00554 Rel homology DNA-binding domain]|[[:Category:NF-kappa-B p65 (Homo sapiens)|Ligand list]]|Transcription factor}}
==Summary==

===Protein Function ===
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PMID: 15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. (From Uniprot)
 

===Cys Function & Property===
Cys38 is very close to the DNA binding site in space. 

* Hydrophobic property:
:[[File:515-hydro.png||600px]]
* SASA：
:Cys38: 58.957 A^2 

==Protein Sequence==

MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYK'''C'''EG RSAGSIPGER 
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY 
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG 
DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN 
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI 
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 
KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP 
FTSSLSTINY DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV 
SALAQAPAPV PVLAPGPPQA VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL 
GALLGNSTDP AVFTDLASVD NSEFQQLLNQ GIPVAPHTTE PMLMEYPEAI 
TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM DFSALLSQIS 
S 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
::[[File:515.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko01523 Antifolate resistance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04010 MAPK signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04014 Ras signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04024 cAMP signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04062 Chemokine signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04064 NF-kappa B signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04066 HIF-1 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04071 Sphingolipid signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04137 Mitophagy - animal] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04151 PI3K-Akt signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04211 Longevity regulating pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04218 Cellular senescence] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04380 Osteoclast differentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04620 Toll-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04621 NOD-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04622 RIG-I-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04623 Cytosolic DNA-sensing pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04625 C-type lectin receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04657 IL-17 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04658 Th1 and Th2 cell differentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04659 Th17 cell differentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04660 T cell receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04662 B cell receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04668 TNF signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04722 Neurotrophin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04917 Prolactin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04920 Adipocytokine signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04926 Relaxin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04931 Insulin resistance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04932 Non-alcoholic fatty liver disease (NAFLD)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04933 AGE-RAGE signaling pathway in diabetic complications] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05030 Cocaine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05120 Epithelial cell signaling in Helicobacter pylori infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05131 Shigellosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05132 Salmonella infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05133 Pertussis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05134 Legionellosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05135 Yersinia infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05140 Leishmaniasis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05142 Chagas disease (American trypanosomiasis)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05145 Toxoplasmosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05146 Amoebiasis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05152 Tuberculosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05160 Hepatitis C] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05161 Hepatitis B] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05162 Measles] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05163 Human cytomegalovirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05164 Influenza A] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05165 Human papillomavirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05166 Human T-cell leukemia virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05167 Kaposi sarcoma-associated herpesvirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05168 Herpes simplex virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05169 Epstein-Barr virus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05170 Human immunodeficiency virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05200 Pathways in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05202 Transcriptional misregulation in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05203 Viral carcinogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05212 Pancreatic cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05215 Prostate cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05220 Chronic myeloid leukemia] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05221 Acute myeloid leukemia] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05222 Small cell lung cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05235 PD-L1 expression and PD-1 checkpoint pathway in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05321 Inflammatory bowel disease (IBD)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05418 Fluid shear stress and atherosclerosis] 

==Experimental Evidence==
:Cys-directed Mutation

==Reference==
# Yadav V R, Prasad S, Gupta S C, et al. '''3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells[J].''' Journal of Biological Chemistry, 2012, 287(1): 245-256. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22065587 22065587] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Transcription factor|Transcription factor]]
[[Category:Rel homology DNA-binding domain|Rel homology DNA-binding domain]]
[[Category:Antifolate resistance|Antifolate resistance]]
[[Category:MAPK signaling pathway|MAPK signaling pathway]]
[[Category:Ras signaling pathway|Ras signaling pathway]]
[[Category:cAMP signaling pathway|cAMP signaling pathway]]
[[Category:Chemokine signaling pathway|Chemokine signaling pathway]]
[[Category:NF-kappa B signaling pathway|NF-kappa B signaling pathway]]
[[Category:HIF-1 signaling pathway|HIF-1 signaling pathway]]
[[Category:Sphingolipid signaling pathway|Sphingolipid signaling pathway]]
[[Category:Mitophagy - animal|Mitophagy - animal]]
[[Category:PI3K-Akt signaling pathway|PI3K-Akt signaling pathway]]
[[Category:Apoptosis|Apoptosis]]
[[Category:Longevity regulating pathway|Longevity regulating pathway]]
[[Category:Cellular senescence|Cellular senescence]]
[[Category:Osteoclast differentiation|Osteoclast differentiation]]
[[Category:Toll-like receptor signaling pathway|Toll-like receptor signaling pathway]]
[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
[[Category:RIG-I-like receptor signaling pathway|RIG-I-like receptor signaling pathway]]
[[Category:Cytosolic DNA-sensing pathway|Cytosolic DNA-sensing pathway]]
[[Category:C-type lectin receptor signaling pathway|C-type lectin receptor signaling pathway]]
[[Category:IL-17 signaling pathway|IL-17 signaling pathway]]
[[Category:Th1 and Th2 cell differentiation|Th1 and Th2 cell differentiation]]
[[Category:Th17 cell differentiation|Th17 cell differentiation]]
[[Category:T cell receptor signaling pathway|T cell receptor signaling pathway]]
[[Category:B cell receptor signaling pathway|B cell receptor signaling pathway]]
[[Category:TNF signaling pathway|TNF signaling pathway]]
[[Category:Neurotrophin signaling pathway|Neurotrophin signaling pathway]]
[[Category:Prolactin signaling pathway|Prolactin signaling pathway]]
[[Category:Adipocytokine signaling pathway|Adipocytokine signaling pathway]]
[[Category:Relaxin signaling pathway|Relaxin signaling pathway]]
[[Category:Insulin resistance|Insulin resistance]]
[[Category:Non-alcoholic fatty liver disease (NAFLD)|Non-alcoholic fatty liver disease (NAFLD)]]
[[Category:AGE-RAGE signaling pathway in diabetic complications|AGE-RAGE signaling pathway in diabetic complications]]
[[Category:Cocaine addiction|Cocaine addiction]]
[[Category:Epithelial cell signaling in Helicobacter pylori infection|Epithelial cell signaling in Helicobacter pylori infection]]
[[Category:Shigellosis|Shigellosis]]
[[Category:Salmonella infection|Salmonella infection]]
[[Category:Pertussis|Pertussis]]
[[Category:Legionellosis|Legionellosis]]
[[Category:Yersinia infection|Yersinia infection]]
[[Category:Leishmaniasis|Leishmaniasis]]
[[Category:Chagas disease|Chagas disease]]
[[Category:Toxoplasmosis|Toxoplasmosis]]
[[Category:Amoebiasis|Amoebiasis]]
[[Category:Tuberculosis|Tuberculosis]]
[[Category:Hepatitis C|Hepatitis C]]
[[Category:Hepatitis B|Hepatitis B]]
[[Category:Measles|Measles]]
[[Category:Human cytomegalovirus infection|Human cytomegalovirus infection]]
[[Category:Influenza A|Influenza A]]
[[Category:Human papillomavirus infection|Human papillomavirus infection]]
[[Category:Human T-cell leukemia virus 1 infection|Human T-cell leukemia virus 1 infection]]
[[Category:Kaposi sarcoma-associated herpesvirus infection|Kaposi sarcoma-associated herpesvirus infection]]
[[Category:Herpes simplex virus 1 infection|Herpes simplex virus 1 infection]]
[[Category:Epstein-Barr virus infection|Epstein-Barr virus infection]]
[[Category:Human immunodeficiency virus 1 infection|Human immunodeficiency virus 1 infection]]
[[Category:Pathways in cancer|Pathways in cancer]]
[[Category:Transcriptional misregulation in cancer|Transcriptional misregulation in cancer]]
[[Category:Viral carcinogenesis|Viral carcinogenesis]]
[[Category:Pancreatic cancer|Pancreatic cancer]]
[[Category:Prostate cancer|Prostate cancer]]
[[Category:Chronic myeloid leukemia|Chronic myeloid leukemia]]
[[Category:Acute myeloid leukemia|Acute myeloid leukemia]]
[[Category:Small cell lung cancer|Small cell lung cancer]]
[[Category:PD-L1 expression and PD-1 checkpoint pathway in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer]]
[[Category:Inflammatory bowel disease (IBD)|Inflammatory bowel disease (IBD)]]
[[Category:Fluid shear stress and atherosclerosis|Fluid shear stress and atherosclerosis]]

@@ Line 114: / Line 114: @@
 # Yadav V R, Prasad S, Gupta S C, et al. '''3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells[J].''' Journal of Biological Chemistry, 2012, 287(1): 245-256. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22065587 22065587]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Transcription factor|Transcription factor]]
+[[Category:Transcription factor]]
-[[Category:Rel homology DNA-binding domain|Rel homology DNA-binding domain]]
+[[Category:Rel homology DNA-binding domain]]
-[[Category:Antifolate resistance|Antifolate resistance]]
+[[Category:Antifolate resistance]]
-[[Category:MAPK signaling pathway|MAPK signaling pathway]]
+[[Category:MAPK signaling pathway]]
-[[Category:Ras signaling pathway|Ras signaling pathway]]
+[[Category:Ras signaling pathway]]
-[[Category:cAMP signaling pathway|cAMP signaling pathway]]
+[[Category:cAMP signaling pathway]]
-[[Category:Chemokine signaling pathway|Chemokine signaling pathway]]
+[[Category:Chemokine signaling pathway]]
-[[Category:NF-kappa B signaling pathway|NF-kappa B signaling pathway]]
+[[Category:NF-kappa B signaling pathway]]
-[[Category:HIF-1 signaling pathway|HIF-1 signaling pathway]]
+[[Category:HIF-1 signaling pathway]]
-[[Category:Sphingolipid signaling pathway|Sphingolipid signaling pathway]]
+[[Category:Sphingolipid signaling pathway]]
-[[Category:Mitophagy - animal|Mitophagy - animal]]
+[[Category:Mitophagy - animal]]
-[[Category:PI3K-Akt signaling pathway|PI3K-Akt signaling pathway]]
+[[Category:PI3K-Akt signaling pathway]]
-[[Category:Apoptosis|Apoptosis]]
+[[Category:Apoptosis]]
-[[Category:Longevity regulating pathway|Longevity regulating pathway]]
+[[Category:Longevity regulating pathway]]
-[[Category:Cellular senescence|Cellular senescence]]
+[[Category:Cellular senescence]]
-[[Category:Osteoclast differentiation|Osteoclast differentiation]]
+[[Category:Osteoclast differentiation]]
-[[Category:Toll-like receptor signaling pathway|Toll-like receptor signaling pathway]]
+[[Category:Toll-like receptor signaling pathway]]
-[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
+[[Category:NOD-like receptor signaling pathway]]
-[[Category:RIG-I-like receptor signaling pathway|RIG-I-like receptor signaling pathway]]
+[[Category:RIG-I-like receptor signaling pathway]]
-[[Category:Cytosolic DNA-sensing pathway|Cytosolic DNA-sensing pathway]]
+[[Category:Cytosolic DNA-sensing pathway]]
-[[Category:C-type lectin receptor signaling pathway|C-type lectin receptor signaling pathway]]
+[[Category:C-type lectin receptor signaling pathway]]
-[[Category:IL-17 signaling pathway|IL-17 signaling pathway]]
+[[Category:IL-17 signaling pathway]]
-[[Category:Th1 and Th2 cell differentiation|Th1 and Th2 cell differentiation]]
+[[Category:Th1 and Th2 cell differentiation]]
-[[Category:Th17 cell differentiation|Th17 cell differentiation]]
+[[Category:Th17 cell differentiation]]
-[[Category:T cell receptor signaling pathway|T cell receptor signaling pathway]]
+[[Category:T cell receptor signaling pathway]]
-[[Category:B cell receptor signaling pathway|B cell receptor signaling pathway]]
+[[Category:B cell receptor signaling pathway]]
-[[Category:TNF signaling pathway|TNF signaling pathway]]
+[[Category:TNF signaling pathway]]
-[[Category:Neurotrophin signaling pathway|Neurotrophin signaling pathway]]
+[[Category:Neurotrophin signaling pathway]]
-[[Category:Prolactin signaling pathway|Prolactin signaling pathway]]
+[[Category:Prolactin signaling pathway]]
-[[Category:Adipocytokine signaling pathway|Adipocytokine signaling pathway]]
+[[Category:Adipocytokine signaling pathway]]
-[[Category:Relaxin signaling pathway|Relaxin signaling pathway]]
+[[Category:Relaxin signaling pathway]]
-[[Category:Insulin resistance|Insulin resistance]]
+[[Category:Insulin resistance]]
-[[Category:Non-alcoholic fatty liver disease (NAFLD)|Non-alcoholic fatty liver disease (NAFLD)]]
+[[Category:Non-alcoholic fatty liver disease (NAFLD)]]
-[[Category:AGE-RAGE signaling pathway in diabetic complications|AGE-RAGE signaling pathway in diabetic complications]]
+[[Category:AGE-RAGE signaling pathway in diabetic complications]]
-[[Category:Cocaine addiction|Cocaine addiction]]
+[[Category:Cocaine addiction]]
-[[Category:Epithelial cell signaling in Helicobacter pylori infection|Epithelial cell signaling in Helicobacter pylori infection]]
+[[Category:Epithelial cell signaling in Helicobacter pylori infection]]
-[[Category:Shigellosis|Shigellosis]]
+[[Category:Shigellosis]]
-[[Category:Salmonella infection|Salmonella infection]]
+[[Category:Salmonella infection]]
-[[Category:Pertussis|Pertussis]]
+[[Category:Pertussis]]
-[[Category:Legionellosis|Legionellosis]]
+[[Category:Legionellosis]]
-[[Category:Yersinia infection|Yersinia infection]]
+[[Category:Yersinia infection]]
-[[Category:Leishmaniasis|Leishmaniasis]]
+[[Category:Leishmaniasis]]
-[[Category:Chagas disease|Chagas disease]]
+[[Category:Chagas disease]]
-[[Category:Toxoplasmosis|Toxoplasmosis]]
+[[Category:Toxoplasmosis]]
-[[Category:Amoebiasis|Amoebiasis]]
+[[Category:Amoebiasis]]
-[[Category:Tuberculosis|Tuberculosis]]
+[[Category:Tuberculosis]]
-[[Category:Hepatitis C|Hepatitis C]]
+[[Category:Hepatitis C]]
-[[Category:Hepatitis B|Hepatitis B]]
+[[Category:Hepatitis B]]
-[[Category:Measles|Measles]]
+[[Category:Measles]]
-[[Category:Human cytomegalovirus infection|Human cytomegalovirus infection]]
+[[Category:Human cytomegalovirus infection]]
-[[Category:Influenza A|Influenza A]]
+[[Category:Influenza A]]
-[[Category:Human papillomavirus infection|Human papillomavirus infection]]
+[[Category:Human papillomavirus infection]]
-[[Category:Human T-cell leukemia virus 1 infection|Human T-cell leukemia virus 1 infection]]
+[[Category:Human T-cell leukemia virus 1 infection]]
-[[Category:Kaposi sarcoma-associated herpesvirus infection|Kaposi sarcoma-associated herpesvirus infection]]
+[[Category:Kaposi sarcoma-associated herpesvirus infection]]
-[[Category:Herpes simplex virus 1 infection|Herpes simplex virus 1 infection]]
+[[Category:Herpes simplex virus 1 infection]]
-[[Category:Epstein-Barr virus infection|Epstein-Barr virus infection]]
+[[Category:Epstein-Barr virus infection]]
-[[Category:Human immunodeficiency virus 1 infection|Human immunodeficiency virus 1 infection]]
+[[Category:Human immunodeficiency virus 1 infection]]
-[[Category:Pathways in cancer|Pathways in cancer]]
+[[Category:Pathways in cancer]]
-[[Category:Transcriptional misregulation in cancer|Transcriptional misregulation in cancer]]
+[[Category:Transcriptional misregulation in cancer]]
-[[Category:Viral carcinogenesis|Viral carcinogenesis]]
+[[Category:Viral carcinogenesis]]
-[[Category:Pancreatic cancer|Pancreatic cancer]]
+[[Category:Pancreatic cancer]]
-[[Category:Prostate cancer|Prostate cancer]]
+[[Category:Prostate cancer]]
-[[Category:Chronic myeloid leukemia|Chronic myeloid leukemia]]
+[[Category:Chronic myeloid leukemia]]
-[[Category:Acute myeloid leukemia|Acute myeloid leukemia]]
+[[Category:Acute myeloid leukemia]]
-[[Category:Small cell lung cancer|Small cell lung cancer]]
+[[Category:Small cell lung cancer]]
-[[Category:PD-L1 expression and PD-1 checkpoint pathway in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer]]
+[[Category:PD-L1 expression and PD-1 checkpoint pathway in cancer]]
-[[Category:Inflammatory bowel disease (IBD)|Inflammatory bowel disease (IBD)]]
+[[Category:Inflammatory bowel disease (IBD)]]
-[[Category:Fluid shear stress and atherosclerosis|Fluid shear stress and atherosclerosis]]
+[[Category:Fluid shear stress and atherosclerosis]]

@@ Line 81: / Line 81: @@
 *[https://www.genome.jp/kegg-bin/show_pathway?ko05135 Yersinia infection] <br/>
 *[https://www.genome.jp/kegg-bin/show_pathway?ko05140 Leishmaniasis] <br/>
-*[https://www.genome.jp/kegg-bin/show_pathway?ko05142 Chagas disease (American trypanosomiasis)] <br/>
+*[https://www.genome.jp/kegg-bin/show_pathway?ko05142 Chagas disease] <br/>
 *[https://www.genome.jp/kegg-bin/show_pathway?ko05145 Toxoplasmosis] <br/>
 *[https://www.genome.jp/kegg-bin/show_pathway?ko05146 Amoebiasis] <br/>

NF-kappa-B p65 (Homo sapiens) - Revision history

Wu3857: /* Reference */

Wu3857: /* Related Pathway */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|NFKB3, Rela, Transcription factor p65|[https://www.uniprot.org/uniprot/Q04206 Q04206]|Homo sapiens|Cys38|[http:..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|NFKB3, Rela, Transcription factor p65|[https://www.uniprot.org/uniprot/Q04206 Q04206]|Homo sapiens|Cys38|[http:..."