Mitochondrial carnitine/acylcarnitine carrier protein - Revision history

Wu3857: /* Reference */

2019-08-19T23:06:23Z

‎Reference

Wu3857 at 01:44, 30 July 2019

2019-07-30T01:44:59Z

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfa..."

2019-07-29T21:42:01Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfa..."

New page

{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfam.org/family/PF00153 Mitochondrial carrier (TC 2.A.29) family]|[[:Category:Mitochondrial carnitine/acylcarnitine carrier protein|Ligand list]]|Transporter}}
==Summary==

===Protein Function ===
This enzyme is required since fatty acids cannot cross the mitochondrial membranes without assistance. The fatty acid is firstly bound to CoA and may cross the external mitochondrial membrane. It then exchanges the CoA for carnitine by the action of the enzyme carnitine palmitoyltransferase I. The complex then enters the mitochondrial matrix thanks to facilitated diffusion by carnitine-acylcarnitine translocase. Here, the acyl-cartinine complex is disrupted by carnitine palmitoyltransferase II and the fatty acid rebinds to CoA. Carnitine then diffuses back across the membrane by carnitine-acylcarnitine translocase into the mitochondrial intermembrane space. This is called the carnitine shuttle system. (From Wiki) 
Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. (From Uniprot) 
CAC is functionally and structurally asymmetrical and it is inserted in the proteoliposomal membrane in a right-side out orientation as compared to mitochondria. (PMID: 24349247)
 

===Cys Function & Property===
To be added 

* Hydrophobic property:
:[[File:497-hydro.png||600px]]
* SASA：
:Cys136: 12.115 A^2
:Cys283: 20.751 A^2

==Protein Sequence==

MAEEPKPISP LKNLLAGGFG GVCLVFVGHP LDTVKVRLQT QPPSLPGQPP 
MYSGTIDCFR KTLFREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKRLQ 
QKSPEDELTY PQLFTAGMLS GVFTTGIMTP GERIK'''C'''LLQI QASSGKNKYS 
GTLDCAKKLY QEFGIRGFYK GTALTLMRDV PASGMYFMTY EWLKNLFTPQ 
GKSVHDLSVP RVLVAGGFRG IFNWVVAIPP DVLKSRFQTA PPGKYPNGFR 
DVLRELIREE GVTSLYKGFN AVMIRAFPAN AA'''C'''FLGFEIP MKILNWIAPN 
L 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
[[File:497.png|center|800px]]

==Related Pathway==
:Unknown 

==Experimental Evidence==
:Cys-directed mutation, Molecular Docking

==Reference==
# Tonazzi A, Eberini I, Indiveri C. Molecular mechanism of inhibition of the mitochondrial carnitine/acylcarnitine transporter by omeprazole revealed by proteoliposome assay, mutagenesis and bioinformatics[J]. PloS one, 2013, 8(12): e82286. [https://www.ncbi.nlm.nih.gov/pubmed/?term=24349247 24349247] 

[[Category:Targets|Targets]]
[[Category:Rattus norvegicus|Rattus norvegicus]]
[[Category:Transporter|Transporter]]
[[Category:Mitochondrial carrier (TC 2.A.29) family|Mitochondrial carrier (TC 2.A.29) family]]

@@ Line 47: / Line 47: @@
 # Tonazzi A, Eberini I, Indiveri C. Molecular mechanism of inhibition of the mitochondrial carnitine/acylcarnitine transporter by omeprazole revealed by proteoliposome assay, mutagenesis and bioinformatics[J]. PloS one, 2013, 8(12): e82286. [https://www.ncbi.nlm.nih.gov/pubmed/?term=24349247 24349247]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Rattus norvegicus|Rattus norvegicus]]
+[[Category:Rattus norvegicus]]
-[[Category:Transporter|Transporter]]
+[[Category:Transporter]]
-[[Category:Mitochondrial carrier (TC 2.A.29) family|Mitochondrial carrier (TC 2.A.29) family]]
+[[Category:Mitochondrial carrier (TC 2.A.29) family]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfam.org/family/PF00153 Mitochondrial carrier (TC 2.A.29) family]|[[:Category:Mitochondrial carnitine/acylcarnitine carrier protein|Ligand list]]|Transporter}}
+{{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfam.org/family/PF00153 Mitochondrial carrier family]|[[:Category:Mitochondrial carnitine/acylcarnitine carrier protein|Ligand list]]|Transporter}}
 ==Summary==

Mitochondrial carnitine/acylcarnitine carrier protein - Revision history

Wu3857: /* Reference */

Wu3857 at 01:44, 30 July 2019

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfa..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CAC, Slc25a20|[https://www.uniprot.org/uniprot/P97521 P97521]|Rattus norvegicus|Cys136, Cys283|[http://pfam.xfa..."