Inosine-5'-monophosphate dehydrogenase 1 - Revision history

Wu3857: /* Reference */

2019-08-19T23:01:43Z

‎Reference

Wu3857 at 02:18, 30 July 2019

2019-07-30T02:18:04Z

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|IMPDH1|[https://www.uniprot.org/uniprot/P20839 P20839]|Homo sapiens|Cys331|[http://pfam.xfam.org/family/PF00478..."

2019-07-30T02:12:05Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|IMPDH1|[https://www.uniprot.org/uniprot/P20839 P20839]|Homo sapiens|Cys331|[http://pfam.xfam.org/family/PF00478..."

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{| align="left"
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{{#invoke:InfoboxforTarget|run|IMPDH1|[https://www.uniprot.org/uniprot/P20839 P20839]|Homo sapiens|Cys331|[http://pfam.xfam.org/family/PF00478 IMPDH/GMPR family]|[[:Category:Inosine-5'-monophosphate dehydrogenase 1|Ligand list]]|Metabolic enzyme}}
==Summary==

===Protein Function ===
IMPDH1 catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. It could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (From Uniprot) 

===Cys Function & Property===
Cys331 is one of the active sites of IMPDH2, acts as the thioimidate intermediate during the catalytic process. 

* Hydrophobic property:
:[[File:499-hydro.png||600px]]
* SASA：
:Cys331: 57.571 A^2 (Due to some missing part)

==Protein Sequence==

MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD 
LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ 
ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM 
GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI 
LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV 
GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI 
GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI '''C'''ITQEVMACG RPQGTAVYKV 
AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY 
FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK 
GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE 
GGVHGLHSYE KRLY 


==Structural Information==
*Known structures with covalent ligands: 
:[https://www.rcsb.org/structure/1JCN 1JCN] 

*Protein structure:
[[File:499.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko00230 Purine metabolism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko00983 Drug metabolism - other enzymes] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko01100 Metabolic pathways] 

==Experimental Evidence==
:Crystallography

==Reference==
# Balzarini J, Karlsson A, Wang L, et al. '''Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis[J].''' Journal of Biological Chemistry, 1993, 268(33): 24591-24598. [https://www.ncbi.nlm.nih.gov/pubmed/?term=7901217 7901217] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Metabolic enzyme|Metabolic enzyme]]
[[Category:IMPDH/GMPR family|IMPDH/GMPR family]]
[[Category:Purine metabolism|Purine metabolism]]
[[Category:Drug metabolism - other enzymes|Drug metabolism - other enzymes]]
[[Category:Metabolic pathways|Metabolic pathways]]

@@ Line 49: / Line 49: @@
 # Balzarini J, Karlsson A, Wang L, et al. '''Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis[J].''' Journal of Biological Chemistry, 1993, 268(33): 24591-24598. [https://www.ncbi.nlm.nih.gov/pubmed/?term=7901217 7901217]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Metabolic enzyme|Metabolic enzyme]]
+[[Category:Metabolic enzyme]]
-[[Category:IMPDH/GMPR family|IMPDH/GMPR family]]
+[[Category:IMPDH/GMPR family]]
-[[Category:Purine metabolism|Purine metabolism]]
+[[Category:Purine metabolism]]
-[[Category:Drug metabolism - other enzymes|Drug metabolism - other enzymes]]
+[[Category:Drug metabolism - other enzymes]]
-[[Category:Metabolic pathways|Metabolic pathways]]
+[[Category:Metabolic pathways]]

@@ Line 14: / Line 14: @@
 :[[File:499-hydro.png||600px]]
 * SASA：
-:Cys331: 57.571 A^2 (Due to some missing part)
+:Cys331: 57.571 A^2
 ==Protein Sequence==

Inosine-5'-monophosphate dehydrogenase 1 - Revision history

Wu3857: /* Reference */

Wu3857 at 02:18, 30 July 2019

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|IMPDH1|[https://www.uniprot.org/uniprot/P20839 P20839]|Homo sapiens|Cys331|[http://pfam.xfam.org/family/PF00478..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|IMPDH1|[https://www.uniprot.org/uniprot/P20839 P20839]|Homo sapiens|Cys331|[http://pfam.xfam.org/family/PF00478..."