Histone acetyltransferase p300 - Revision history

Wu3857: /* Reference */

2019-08-19T23:01:07Z

‎Reference

Wu3857 at 03:07, 15 August 2019

2019-08-15T03:07:07Z

Wu3857: /* Reference */

2019-08-07T21:03:13Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/fami..."

2019-08-07T20:59:03Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/fami..."

New page

{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/family/PF08214 Histone acetylation protein]|[[:Category:Histone acetyltransferase p300|Ligand list]]|Post-translational Modification}}

==Summary==

===Protein Function ===
p300 HAT functions as histone acetyltransferase that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. 
p300 HAT contains a bromodomain which is involved in IL6 signaling. 
This protein has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (From Wikipedia)
 
acetyl-CoA + L-lysyl-[protein] = CoA + H+ + N6-acetyl-L-lysyl-[protein] 

===Cys Function & Property===
Cys1438 is close to the cofactor Acetyl-CoA binding site in space. 

* Hydrophobic property:
:[[File:538-hydro.png||600px]]
* SASA：
:Cys1438: 39.714 A^2

==Protein Sequence==

MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS 
TELGLTNGGD INQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP 
GQVMASQAQQ SSPGLGLINS MVKSPMTQAG LTSPNMGMGT SGPNQGPTQS 
TGMMNSPVNQ PAMGMNTGMN AGMNPGMLAA GNGQGIMPNQ VMNGSIGAGR 
GRQNMQYPNP GMGSAGNLLT EPLQQGSPQM GGQTGLRGPQ PLKMGMMNNP 
NPYGSPYTQN PGQQIGASGL GLQIQTKTVL SNNLSPFAMD KKAVPGGGMP 
NMGQQPAPQV QQPGLVTPVA QGMGSGAHTA DPEKRKLIQQ QLVLLLHAHK 
CQRREQANGE VRQCNLPHCR TMKNVLNHMT HCQSGKSCQV AHCASSRQII 
SHWKNCTRHD CPVCLPLKNA GDKRNQQPIL TGAPVGLGNP SSLGVGQQSA 
PNLSTVSQID PSSIERAYAA LGLPYQVNQM PTQPQVQAKN QQNQQPGQSP 
QGMRPMSNMS ASPMGVNGGV GVQTPSLLSD SMLHSAINSQ NPMMSENASV 
PSLGPMPTAA QPSTTGIRKQ WHEDITQDLR NHLVHKLVQA IFPTPDPAAL 
KDRRMENLVA YARKVEGDMY ESANNRAEYY HLLAEKIYKI QKELEEKRRT 
RLQKQNMLPN AAGMVPVSMN PGPNMGQPQP GMTSNGPLPD PSMIRGSVPN 
QMMPRITPQS GLNQFGQMSM AQPPIVPRQT PPLQHHGQLA QPGALNPPMG 
YGPRMQQPSN QGQFLPQTQF PSQGMNVTNI PLAPSSGQAP VSQAQMSSSS 
CPVNSPIMPP GSQGSHIHCP QLPQPALHQN SPSPVPSRTP TPHHTPPSIG 
AQQPPATTIP APVPTPPAMP PGPQSQALHP PPRQTPTPPT TQLPQQVQPS 
LPAAPSADQP QQQPRSQQST AASVPTPTAP LLPPQPATPL SQPAVSIEGQ 
VSNPPSTSST EVNSQAIAEK QPSQEVKMEA KMEVDQPEPA DTQPEDISES 
KVEDCKMEST ETEERSTELK TEIKEEEDQP STSATQSSPA PGQSKKKIFK 
PEELRQALMP TLEALYRQDP ESLPFRQPVD PQLLGIPDYF DIVKSPMDLS 
TIKRKLDTGQ YQEPWQYVDD IWLMFNNAWL YNRKTSRVYK YCSKLSEVFE 
QEIDPVMQSL GYCCGRKLEF SPQTLCCYGK QLCTIPRDAT YYSYQNRYHF 
CEKCFNEIQG ESVSLGDDPS QPQTTINKEQ FSKRKNDTLD PELFVECTEC 
GRKMHQICVL HHEIIWPAGF VCDGCLKKSA RTRKENKFSA KRLPSTRLGT 
FLENRVNDFL RRQNHPESGE VTVRVVHASD KTVEVKPGMK ARFVDSGEMA 
ESFPYRTKAL FAFEEIDGVD LCFFGMHVQE YGSDCPPPNQ RRVYISYLDS 
VHFFRPKCLR TAVYHEILIG YLEYVKKLGY TTGHIWA'''C'''PP SEGDDYIFHC 
HPPDQKIPKP KRLQEWYKKM LDKAVSERIV HDYKDIFKQA TEDRLTSAKE 
LPYFEGDFWP NVLEESIKEL EQEEEERKRE ENTSNESTDV TKGDSKNAKK 
KNNKKTSKNK SSLSRGNKKK PGMPNVSNDL SQKLYATMEK HKEVFFVIRL 
IAGPAANSLP PIVDPDPLIP CDLMDGRDAF LTLARDKHLE FSSLRRAQWS 
TMCMLVELHT QSQDRFVYTC NECKHHVETR WHCTVCEDYD LCITCYNTKN 
HDHKMEKLGL GLDDESNNQQ AAATQSPGDS RRLSIQRCIQ SLVHACQCRN 
ANCSLPSCQK MKRVVQHTKG CKRKTNGGCP ICKQLIALCC YHAKHCQENK 
CPVPFCLNIK QKLRQQQLQH RLQQAQMLRR RMASMQRTGV VGQQQGLPSP 
TPATPTTPTG QQPTTPQTPQ PTSQPQPTPP NSMPPYLPRT QAAGPVSQGK 
AAGQVTPPTP PQTAQPPLPG PPPAAVEMAM QIQRAAETQR QMAHVQIFQR 
PIQHQMPPMT PMAPMGMNPP PMTRGPSGHL EPGMGPTGMQ QQPPWSQGGL 
PQPQQLQSGM PRPAMMSVAQ HGQPLNMAPQ PGLGQVGISP LKPGTVSQQA 
LQNLLRTLRS PSSPLQQQQV LSILHANPQL LAAFIKQRAA KYANSNPQPI 
PGQPGMPQGQ PGLQPPTMPG QQGVHSNPAM QNMNPMQAGV QRAGLPQQQP 
QQQLQPPMGG MSPQAQQMNM NHNTMPSQFR DILRRQQMMQ QQQQQGAGPG 
IGPGMANHNQ FQQPQGVGYP PQQQQRMQHH MQQMQQGNMG QIGQLPQALG 
AEAGASLQAY QQRLLQQQMG SPVQPNPMSP QQHMLPNQAQ SPHLQGQQIP 
NSLSNQVRSP QPVPSPRPQS QPPHSSPSPR MQPQPSPHHV SPQTSSPHPG 
LVAAQANPME QGHFASPDQN SMLSQLASNP GMANLHGASA TDLGLSTDNS 
DLNSNLSQST LDIH 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
[[File:538.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04024 cAMP signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04066 HIF-1 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04068 FoxO signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04110 Cell cycle] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04310 Wnt signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04330 Notch signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04350 TGF-beta signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04520 Adherens junction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04630 Jak-STAT signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04720 Long-term potentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04916 Melanogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04919 Thyroid hormone signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04922 Glucagon signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05016 Huntington disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05152 Tuberculosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05161 Hepatitis B] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05164 Influenza A] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05165 Human papillomavirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05166 Human T-cell leukemia virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05167 Kaposi sarcoma-associated herpesvirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05200 Pathways in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05203 Viral carcinogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05206 MicroRNAs in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05211 Renal cell carcinoma] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05215 Prostate cancer] 

==Experimental Evidence==
:Cys-directed Mutation

==Reference==
# Pereira S R, Vasconcelos V M, Antunes A. '''Computational study of the covalent bonding of microcystins to cysteine residues–a reaction involved in the inhibition of the PPP family of protein phosphatases[J].''' The FEBS journal, 2013, 280(2): 674-680. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22177231 22177231] 
# MacKintosh R W, Dalby K N, Campbell D G, et al. '''The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1[J].''' Febs Letters, 1995, 371(3): 236-240. [https://www.ncbi.nlm.nih.gov/pubmed/?term=7556599 7556599] 
# Hastie C J, Borthwick E B, Morrison L F, et al. '''Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclin[J].''' Biochimica et Biophysica Acta (BBA)-General Subjects, 2005, 1726(2): 187-193. [https://www.ncbi.nlm.nih.gov/pubmed/?term=16046071 16046071] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Post-translational Modification|Post-translational Modification]]
[[Category:Histone acetylation protein|Histone acetylation protein]]
[[Category:cAMP signaling pathway|cAMP signaling pathway]]
[[Category:HIF-1 signaling pathway|HIF-1 signaling pathway]]
[[Category:FoxO signaling pathway|FoxO signaling pathway]]
[[Category:Cell cycle|Cell cycle]]
[[Category:Wnt signaling pathway|Wnt signaling pathway]]
[[Category:Notch signaling pathway|Notch signaling pathway]]
[[Category:TGF-beta signaling pathway|TGF-beta signaling pathway]]
[[Category:Adherens junction|Adherens junction]]
[[Category:Jak-STAT signaling pathway|Jak-STAT signaling pathway]]
[[Category:Long-term potentiation|Long-term potentiation]]
[[Category:Melanogenesis|Melanogenesis]]
[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
[[Category:Glucagon signaling pathway|Glucagon signaling pathway]]
[[Category:Huntington disease|Huntington disease]]
[[Category:Tuberculosis|Tuberculosis]]
[[Category:Hepatitis B|Hepatitis B]]
[[Category:Influenza A|Influenza A]]
[[Category:Human papillomavirus infection|Human papillomavirus infection]]
[[Category:Human T-cell leukemia virus 1 infection|Human T-cell leukemia virus 1 infection]]
[[Category:Kaposi sarcoma-associated herpesvirus infection|Kaposi sarcoma-associated herpesvirus infection]]
[[Category:Pathways in cancer|Pathways in cancer]]
[[Category:Viral carcinogenesis|Viral carcinogenesis]]
[[Category:MicroRNAs in cancer|MicroRNAs in cancer]]
[[Category:Renal cell carcinoma|Renal cell carcinoma]]
[[Category:Prostate cancer|Prostate cancer]]

@@ Line 114: / Line 114: @@
 # Ravindra K C, Narayan V, Lushington G H, et al. '''Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ<sup>12</sup>-PGJ<sub>2</sub> through Covalent Binding to Cys1438[J].''' Chemical research in toxicology, 2011, 25(2): 337-347. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22141352 22141352]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Post-translational Modification|Post-translational Modification]]
+[[Category:Post-translational Modification]]
-[[Category:Transcription Related|Transcription Related]]
+[[Category:Transcription Related]]
-[[Category:Histone acetylation protein|Histone acetylation protein]]
+[[Category:Histone acetylation protein]]
-[[Category:cAMP signaling pathway|cAMP signaling pathway]]
+[[Category:cAMP signaling pathway]]
-[[Category:HIF-1 signaling pathway|HIF-1 signaling pathway]]
+[[Category:HIF-1 signaling pathway]]
-[[Category:FoxO signaling pathway|FoxO signaling pathway]]
+[[Category:FoxO signaling pathway]]
-[[Category:Cell cycle|Cell cycle]]
+[[Category:Cell cycle]]
-[[Category:Wnt signaling pathway|Wnt signaling pathway]]
+[[Category:Wnt signaling pathway]]
-[[Category:Notch signaling pathway|Notch signaling pathway]]
+[[Category:Notch signaling pathway]]
-[[Category:TGF-beta signaling pathway|TGF-beta signaling pathway]]
+[[Category:TGF-beta signaling pathway]]
-[[Category:Adherens junction|Adherens junction]]
+[[Category:Adherens junction]]
-[[Category:Jak-STAT signaling pathway|Jak-STAT signaling pathway]]
+[[Category:Jak-STAT signaling pathway]]
-[[Category:Long-term potentiation|Long-term potentiation]]
+[[Category:Long-term potentiation]]
-[[Category:Melanogenesis|Melanogenesis]]
+[[Category:Melanogenesis]]
-[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
+[[Category:Thyroid hormone signaling pathway]]
-[[Category:Glucagon signaling pathway|Glucagon signaling pathway]]
+[[Category:Glucagon signaling pathway]]
-[[Category:Huntington disease|Huntington disease]]
+[[Category:Huntington disease]]
-[[Category:Tuberculosis|Tuberculosis]]
+[[Category:Tuberculosis]]
-[[Category:Hepatitis B|Hepatitis B]]
+[[Category:Hepatitis B]]
-[[Category:Influenza A|Influenza A]]
+[[Category:Influenza A]]
-[[Category:Human papillomavirus infection|Human papillomavirus infection]]
+[[Category:Human papillomavirus infection]]
-[[Category:Human T-cell leukemia virus 1 infection|Human T-cell leukemia virus 1 infection]]
+[[Category:Human T-cell leukemia virus 1 infection]]
-[[Category:Kaposi sarcoma-associated herpesvirus infection|Kaposi sarcoma-associated herpesvirus infection]]
+[[Category:Kaposi sarcoma-associated herpesvirus infection]]
-[[Category:Pathways in cancer|Pathways in cancer]]
+[[Category:Pathways in cancer]]
-[[Category:Viral carcinogenesis|Viral carcinogenesis]]
+[[Category:Viral carcinogenesis]]
-[[Category:MicroRNAs in cancer|MicroRNAs in cancer]]
+[[Category:MicroRNAs in cancer]]
-[[Category:Renal cell carcinoma|Renal cell carcinoma]]
+[[Category:Renal cell carcinoma]]
-[[Category:Prostate cancer|Prostate cancer]]
+[[Category:Prostate cancer]]

@@ Line 112: / Line 112: @@
 ==Reference==
-# Pereira S R, Vasconcelos V M, Antunes A. '''Computational study of the covalent bonding of microcystins to cysteine residues–a reaction involved in the inhibition of the PPP family of protein phosphatases[J].''' The FEBS journal, 2013, 280(2): 674-680. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22177231 22177231]<br/>
+# Ravindra K C, Narayan V, Lushington G H, et al. '''Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ<sup>12</sup>-PGJ<sub>2</sub> through Covalent Binding to Cys1438[J].''' Chemical research in toxicology, 2011, 25(2): 337-347. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22141352 22141352]<br/>
 [[Category:Targets|Targets]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/family/PF08214 Histone acetylation protein]|[[:Category:Histone acetyltransferase p300|Ligand list]]|Post-translational Modification}}
+{{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/family/PF08214 Histone acetylation protein]|[[:Category:Histone acetyltransferase p300|Ligand list]]|Post-translational Modification, Transcription Related}}
 ==Summary==
@@ Line 117: / Line 117: @@
 [[Category:Homo sapiens|Homo sapiens]]
 [[Category:Post-translational Modification|Post-translational Modification]]
 [[Category:Histone acetylation protein|Histone acetylation protein]]
 [[Category:cAMP signaling pathway|cAMP signaling pathway]]

Histone acetyltransferase p300 - Revision history

Wu3857: /* Reference */

Wu3857 at 03:07, 15 August 2019

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/fami..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|EP300, p300 HAT|[https://www.uniprot.org/uniprot/Q09472 Q09472]|Homo sapiens|Cys1438|[http://pfam.xfam.org/fami..."