Wu3857: /* Summary */

2020-04-28T03:54:04Z

‎Summary

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|HBB|[https://www.uniprot.org/uniprot/P68871 P68871]|Homo sapiens|Cys94|[http://pfam.xfam.org/family/PF00042 Glo..."

2020-04-28T03:53:50Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|HBB|[https://www.uniprot.org/uniprot/P68871 P68871]|Homo sapiens|Cys94|[http://pfam.xfam.org/family/PF00042 Glo..."

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{| align="left"
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{{#invoke:InfoboxforTarget|run|HBB|[https://www.uniprot.org/uniprot/P68871 P68871]|Homo sapiens|Cys94|[http://pfam.xfam.org/family/PF00042 Globin family]|[[:Category:Hemoglobin subunit beta|Ligand list]]|Transporter}}

==Summary==

===Protein Function ===
Beta globin (also referred to as HBB, β-globin, haemoglobin beta, hemoglobin beta, or preferably haemoglobin subunit beta) is a globin protein, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, the HbA. It is 146 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains. 
HBB is encoded by the HBB gene on human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. (From Wikipedia) 

===Cys Function & Property===
Cys94 is besides the metal binding site of HBB, His93. 

* Hydrophobic property:
:[[File:600-hydro.png||600px]]
* SASA：
:Cys94: 7.012 A^2 

==Protein Sequence==

MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS 
TPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELH'''C'''DKLHVD 
PENFRLLGNV LVCVLAHHFG KEFTPPVQAA YQKVVAGVAN ALAHKYH 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:[[File:600.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko05143 African trypanosomiasis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05144 Malaria] 

==Experimental Evidence==
:FTIR spectra, Electrospray Mass Spectra

==Reference==
# Romeo A A, Filosa A, Capobianco J A, et al. Metal chelators inhibit S-nitrosation of Cysβ93 in oxyhemoglobin[J]. Journal of the American Chemical Society, 2001, 123(8): 1782-1783. [https://www.ncbi.nlm.nih.gov/pubmed/?term=11456789 11456789] 

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Transporter]]
[[Category:Globin family]]
[[Category:African trypanosomiasis]]
[[Category:Malaria]]

@@ Line 9: / Line 9: @@
 Beta globin (also referred to as HBB, β-globin, haemoglobin beta, hemoglobin beta, or preferably haemoglobin subunit beta) is a globin protein, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, the HbA. It is 146 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains.  <br/>
 HBB is encoded by the HBB gene on human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. (From Wikipedia) <br/>
+<br/>
 ===Cys Function & Property===
 Cys94 is besides the metal binding site of HBB, His93. <br/>

Hemoglobin subunit beta - Revision history

Wu3857: /* Summary */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|HBB|[https://www.uniprot.org/uniprot/P68871 P68871]|Homo sapiens|Cys94|[http://pfam.xfam.org/family/PF00042 Glo..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|HBB|[https://www.uniprot.org/uniprot/P68871 P68871]|Homo sapiens|Cys94|[http://pfam.xfam.org/family/PF00042 Glo..."