Glutamate receptor ionotropic, NMDA 2A - Revision history

Wu3857: /* Reference */

2019-08-19T22:51:45Z

‎Reference

Wu3857: /* Reference */

2019-08-10T03:11:17Z

‎Reference

Wu3857: /* Protein Function */

2019-08-10T03:10:20Z

‎Protein Function

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|GluN2A, NMDAR2A|[https://www.uniprot.org/uniprot/Q12879 Q12879]|Homo sapiens|Cys87, Cys320, Cys399|Glutamate-ga..."

2019-08-10T03:09:23Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|GluN2A, NMDAR2A|[https://www.uniprot.org/uniprot/Q12879 Q12879]|Homo sapiens|Cys87, Cys320, Cys399|Glutamate-ga..."

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{| align="left"
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{{#invoke:InfoboxforTarget|run|GluN2A, NMDAR2A|[https://www.uniprot.org/uniprot/Q12879 Q12879]|Homo sapiens|Cys87, Cys320, Cys399|Glutamate-gated ion channel family, NR2A/GRIN2A subfamily|[[:Category:Glutamate receptor ionotropic, NMDA 2A|Ligand list]]|Ion channel}}
==Summary==

===Protein Function ===
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function. 
The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations with a reversal potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ & Zn2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent. 
Calcium flux through NMDARs is thought to be critical in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: first, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands: glutamate and either D-serine or glycine. 
The activity of the NMDA receptor is affected by many psychoactive drugs such as phencyclidine (PCP), alcohol (ethanol) and dextromethorphan (DXM). The anaesthetic effects of the drugs ketamine and nitrous oxide are partially because of their effects on NMDA receptor activity. (From Wikipedia) 
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. (From Uniprot) 

===Cys Function & Property===
* Hydrophobic property:
:[[File:550-hydro.png||600px]]
* SASA：
:Cys87: Unknown 
:Cys320: Unknown 
:Cys399: Unknown 

==Protein Sequence==

MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE 
LRTLWGPEQA AGLPLDVNVV ALLMNRTDPK SLITHV'''C'''DLM SGARIHGLVF 
GDDTDQEAVA QMLDFISSHT FVPILGIHGG ASMIMADKDP TSTFFQFGAS 
IQQQATVMLK IMQDYDWHVF SLVTTIFPGY REFISFVKTT VDNSFVGWDM 
QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL SEARSLGLTG 
YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT 
TAASSMLEKF SYIPEAKAS'''C''' YGQMERPEVP MHTLHPFMVN VTWDGKDLSF 
TEEGYQVHPR LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSD'''C'''E 
PDDNHLSIVT LEEAPFVIVE DIDPLTETCV RNTVPCRKFV KINNSTNEGM 
NVKKCCKGFC IDILKKLSRT VKFTYDLYLV TNGKHGKKVN NVWNGMIGEV 
VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS NGTVSPSAFL 
EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA 
AFMIQEEFVD QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY 
MHQYMTKFNQ KGVEDALVSL KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI 
GSGYIFATTG YGIALQKGSP WKRQIDLALL QFVGDGEMEE LETLWLTGIC 
HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL FYWKLRFCFT 
GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ 
GKESIFGDNM NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV 
STESKANSRP RQLWKKSVDS IRQDSLSQNP VSQRDEATAE NRTHSLKSPR 
YLPEEMAHSD ISETSNRATC HREPDNSKNH KTKDNFKRSV ASKYPKDCSE 
VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT LPENVDFPDP 
YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH 
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE 
DQMLQETGNP ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR 
ELDLSRPSRS ISLKDRERLL EGNFYGSLFS VPSSKLSGKK SSLFPQGLED 
SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG RCPSDPYKHS LPSQAVNDSY 
LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS TPRVLNSCSN 
RRVYKKMPSI ESDV 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:Unknown 

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04014 Ras signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04015 Rap1 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04020 Calcium signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04024 cAMP signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04080 Neuroactive ligand-receptor interaction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04713 Circadian entrainment] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04720 Long-term potentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04724 Glutamatergic synapse] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05010 Alzheimer disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04728 Dopaminergic synapse] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05014 Amyotrophic lateral sclerosis (ALS)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05030 Cocaine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05031 Amphetamine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05033 Nicotine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05034 Alcoholism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05322 Systemic lupus erythematosus] 

==Experimental Evidence==
:Cys-directed Mutation

==Reference==
# Kim W K, Choi Y B, Rayudu P V, et al. '''Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO−[J].''' Neuron, 1999, 24(2): 461-469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10571239 10571239] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Ion channel|Ion channel]]
[[Category:Glutamate-gated ion channel family|Glutamate-gated ion channel family]]
[[Category:NR1/GRIN1 subfamily|NR1/GRIN1 subfamily]]
[[Category:Ras signaling pathway|Ras signaling pathway]]
[[Category:Rap1 signaling pathway|Rap1 signaling pathway]]
[[Category:Calcium signaling pathway|Calcium signaling pathway]]
[[Category:cAMP signaling pathway|cAMP signaling pathway]]
[[Category:Neuroactive ligand-receptor interaction|Neuroactive ligand-receptor interaction]]
[[Category:Circadian entrainment|Circadian entrainment]]
[[Category:Long-term potentiation|Long-term potentiation]]
[[Category:Glutamatergic synapse|Glutamatergic synapse]]
[[Category:Alzheimer disease|Alzheimer disease]]
[[Category:Amyotrophic lateral sclerosis (ALS)|Amyotrophic lateral sclerosis (ALS)]]
[[Category:Dopaminergic synapse|Dopaminergic synapse]]
[[Category:Cocaine addiction|Cocaine addiction]]
[[Category:Amphetamine addiction|Amphetamine addiction]]
[[Category:Nicotine addiction|Nicotine addiction]]
[[Category:Alcoholism|Alcoholism]]
[[Category:Systemic lupus erythematosus|Systemic lupus erythematosus]]

@@ Line 86: / Line 86: @@
 # Kim W K, Choi Y B, Rayudu P V, et al. '''Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO−[J].''' Neuron, 1999, 24(2): 461-469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10571239 10571239]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Ion channel|Ion channel]]
+[[Category:Ion channel]]
-[[Category:Glutamate-gated ion channel family|Glutamate-gated ion channel family]]
+[[Category:Glutamate-gated ion channel family]]
-[[Category:NR2A/GRIN2A subfamily|NR2A/GRIN2A subfamily]]
+[[Category:NR2A/GRIN2A subfamily]]
-[[Category:Ras signaling pathway|Ras signaling pathway]]
+[[Category:Ras signaling pathway]]
-[[Category:Rap1 signaling pathway|Rap1 signaling pathway]]
+[[Category:Rap1 signaling pathway]]
-[[Category:Calcium signaling pathway|Calcium signaling pathway]]
+[[Category:Calcium signaling pathway]]
-[[Category:cAMP signaling pathway|cAMP signaling pathway]]
+[[Category:cAMP signaling pathway]]
-[[Category:Neuroactive ligand-receptor interaction|Neuroactive ligand-receptor interaction]]
+[[Category:Neuroactive ligand-receptor interaction]]
-[[Category:Circadian entrainment|Circadian entrainment]]
+[[Category:Circadian entrainment]]
-[[Category:Long-term potentiation|Long-term potentiation]]
+[[Category:Long-term potentiation]]
-[[Category:Glutamatergic synapse|Glutamatergic synapse]]
+[[Category:Glutamatergic synapse]]
-[[Category:Alzheimer disease|Alzheimer disease]]
+[[Category:Alzheimer disease]]
-[[Category:Amyotrophic lateral sclerosis (ALS)|Amyotrophic lateral sclerosis (ALS)]]
+[[Category:Amyotrophic lateral sclerosis (ALS)]]
-[[Category:Dopaminergic synapse|Dopaminergic synapse]]
+[[Category:Dopaminergic synapse]]
-[[Category:Cocaine addiction|Cocaine addiction]]
+[[Category:Cocaine addiction]]
-[[Category:Amphetamine addiction|Amphetamine addiction]]
+[[Category:Amphetamine addiction]]
-[[Category:Nicotine addiction|Nicotine addiction]]
+[[Category:Nicotine addiction]]
-[[Category:Alcoholism|Alcoholism]]
+[[Category:Alcoholism]]
-[[Category:Systemic lupus erythematosus|Systemic lupus erythematosus]]
+[[Category:Systemic lupus erythematosus]]

@@ Line 7: / Line 7: @@
 ===Protein Function ===
 The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function. <br/>
-The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations with a reversal potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ & Zn2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent. <br/>
+The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations with a reversal potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg<sup>2+</sup> & Zn<sup>2+</sup> ions. This allows the flow of Na<sup>+</sup> and small amounts of Ca<sup>2+</sup> ions into the cell and K<sup>+</sup> out of the cell to be voltage-dependent. <br/>
 Calcium flux through NMDARs is thought to be critical in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: first, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands: glutamate and either D-serine or glycine. <br/>
 The activity of the NMDA receptor is affected by many psychoactive drugs such as phencyclidine (PCP), alcohol (ethanol) and dextromethorphan (DXM). The anaesthetic effects of the drugs ketamine and nitrous oxide are partially because of their effects on NMDA receptor activity. (From Wikipedia)<br/>

Glutamate receptor ionotropic, NMDA 2A - Revision history

Wu3857: /* Reference */

Wu3857: /* Reference */

Wu3857: /* Protein Function */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|GluN2A, NMDAR2A|[https://www.uniprot.org/uniprot/Q12879 Q12879]|Homo sapiens|Cys87, Cys320, Cys399|Glutamate-ga..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|GluN2A, NMDAR2A|[https://www.uniprot.org/uniprot/Q12879 Q12879]|Homo sapiens|Cys87, Cys320, Cys399|Glutamate-ga..."