Glutamate receptor ionotropic, NMDA 1 - Revision history

Wu3857: /* Reference */

2019-08-19T22:50:23Z

‎Reference

Wu3857: /* Protein Function */

2019-08-10T02:49:13Z

‎Protein Function

Wu3857: /* Protein Function */

2019-08-10T02:49:07Z

‎Protein Function

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Glun1, GRIN1, NMDA1|[https://www.uniprot.org/uniprot/Q05586 Q05586]|Homo sapiens|Cys744, Cys798|Glutamate-gated..."

2019-08-10T02:48:53Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Glun1, GRIN1, NMDA1|[https://www.uniprot.org/uniprot/Q05586 Q05586]|Homo sapiens|Cys744, Cys798|Glutamate-gated..."

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{{#invoke:InfoboxforTarget|run|Glun1, GRIN1, NMDA1|[https://www.uniprot.org/uniprot/Q05586 Q05586]|Homo sapiens|Cys744, Cys798|Glutamate-gated ion channel family, NR1/GRIN1 subfamily|[[:Category:Glutamate receptor ionotropic, NMDA 1|Ligand list]]|Ion channel}}
==Summary==

===Protein Function ===
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. (From Uniprot) 
[[File:549-function.png|center|600px]]

===Cys Function & Property===
* Hydrophobic property:
:[[File:549-hydro.png||600px]]
* SASA：
:Cys744: Unknown 
:Cys798: Unknown 

==Protein Sequence==

MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN 
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND 
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV 
WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG 
TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG 
EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN 
YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI 
VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT 
VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG 
MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST 
LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN 
LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS 
TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQK'''C'''DLVTTG 
ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQE'''C'''DS 
RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL 
AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT 
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:Unknown 

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04014 Ras signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04015 Rap1 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04020 Calcium signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04024 cAMP signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04080 Neuroactive ligand-receptor interaction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04713 Circadian entrainment] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04720 Long-term potentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04724 Glutamatergic synapse] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05010 Alzheimer disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05014 Amyotrophic lateral sclerosis (ALS)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05016 Huntington disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05030 Cocaine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05031 Amphetamine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05033 Nicotine addiction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05034 Alcoholism] 

==Experimental Evidence==
:Cys-directed Mutation

==Reference==
# Kim W K, Choi Y B, Rayudu P V, et al. '''Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO−[J].''' Neuron, 1999, 24(2): 461-469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10571239 10571239] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Ion channel|Ion channel]]
[[Category:Glutamate-gated ion channel family|Glutamate-gated ion channel family]]
[[Category:NR1/GRIN1 subfamily|NR1/GRIN1 subfamily]]
[[Category:Ras signaling pathway|Ras signaling pathway]]
[[Category:Rap1 signaling pathway|Rap1 signaling pathway]]
[[Category:Calcium signaling pathway|Calcium signaling pathway]]
[[Category:cAMP signaling pathway|cAMP signaling pathway]]
[[Category:Neuroactive ligand-receptor interaction|Neuroactive ligand-receptor interaction]]
[[Category:Circadian entrainment|Circadian entrainment]]
[[Category:Long-term potentiation|Long-term potentiation]]
[[Category:Glutamatergic synapse|Glutamatergic synapse]]
[[Category:Alzheimer disease|Alzheimer disease]]
[[Category:Amyotrophic lateral sclerosis (ALS)|Amyotrophic lateral sclerosis (ALS)]]
[[Category:Huntington disease|Huntington disease]]
[[Category:Cocaine addiction|Cocaine addiction]]
[[Category:Amphetamine addiction|Amphetamine addiction]]
[[Category:Nicotine addiction|Nicotine addiction]]
[[Category:Alcoholism|Alcoholism]]

@@ Line 69: / Line 69: @@
 # Kim W K, Choi Y B, Rayudu P V, et al. '''Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO−[J].''' Neuron, 1999, 24(2): 461-469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10571239 10571239]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Ion channel|Ion channel]]
+[[Category:Ion channel]]
-[[Category:Glutamate-gated ion channel family|Glutamate-gated ion channel family]]
+[[Category:Glutamate-gated ion channel family]]
-[[Category:NR1/GRIN1 subfamily|NR1/GRIN1 subfamily]]
+[[Category:NR1/GRIN1 subfamily]]
-[[Category:Ras signaling pathway|Ras signaling pathway]]
+[[Category:Ras signaling pathway]]
-[[Category:Rap1 signaling pathway|Rap1 signaling pathway]]
+[[Category:Rap1 signaling pathway]]
-[[Category:Calcium signaling pathway|Calcium signaling pathway]]
+[[Category:Calcium signaling pathway]]
-[[Category:cAMP signaling pathway|cAMP signaling pathway]]
+[[Category:cAMP signaling pathway]]
-[[Category:Neuroactive ligand-receptor interaction|Neuroactive ligand-receptor interaction]]
+[[Category:Neuroactive ligand-receptor interaction]]
-[[Category:Circadian entrainment|Circadian entrainment]]
+[[Category:Circadian entrainment]]
-[[Category:Long-term potentiation|Long-term potentiation]]
+[[Category:Long-term potentiation]]
-[[Category:Glutamatergic synapse|Glutamatergic synapse]]
+[[Category:Glutamatergic synapse]]
-[[Category:Alzheimer disease|Alzheimer disease]]
+[[Category:Alzheimer disease]]
-[[Category:Amyotrophic lateral sclerosis (ALS)|Amyotrophic lateral sclerosis (ALS)]]
+[[Category:Amyotrophic lateral sclerosis (ALS)]]
-[[Category:Huntington disease|Huntington disease]]
+[[Category:Huntington disease]]
-[[Category:Cocaine addiction|Cocaine addiction]]
+[[Category:Cocaine addiction]]
-[[Category:Amphetamine addiction|Amphetamine addiction]]
+[[Category:Amphetamine addiction]]
-[[Category:Nicotine addiction|Nicotine addiction]]
+[[Category:Nicotine addiction]]
-[[Category:Alcoholism|Alcoholism]]
+[[Category:Alcoholism]]

@@ Line 7: / Line 7: @@
 ===Protein Function ===
 NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. (From Uniprot)<br/>
-[[File:549-function.png|center|500px]]
+[[File:549-function.png|center|400px]]
 ===Cys Function & Property===

Glutamate receptor ionotropic, NMDA 1 - Revision history

Wu3857: /* Reference */

Wu3857: /* Protein Function */

Wu3857: /* Protein Function */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Glun1, GRIN1, NMDA1|[https://www.uniprot.org/uniprot/Q05586 Q05586]|Homo sapiens|Cys744, Cys798|Glutamate-gated..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Glun1, GRIN1, NMDA1|[https://www.uniprot.org/uniprot/Q05586 Q05586]|Homo sapiens|Cys744, Cys798|Glutamate-gated..."