GTPase HRas - Revision history

Wu3857: /* Reference */

2019-08-19T23:00:26Z

‎Reference

Wu3857 at 02:59, 10 August 2019

2019-08-10T02:59:43Z

Wu3857: /* Cys Function & Property */

2019-07-31T18:16:53Z

‎Cys Function & Property

Wu3857: /* Structural Information */

2019-07-31T03:56:00Z

‎Structural Information

Wu3857: /* Cys Function & Property */

2019-07-31T03:39:29Z

‎Cys Function & Property

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|[http://pfam.xfam.org/..."

2019-07-31T03:38:36Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|[http://pfam.xfam.org/..."

New page

{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|[http://pfam.xfam.org/family/PF00071 Ras family], Small GTPase superfamily|[[:Category:GTPase HRas|Ligand list]]|ATPase/GTPase}}
==Summary==

===Protein Function ===
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (From Uniprot) 
GTPase HRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene. The HRAS gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549. HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase like c-Raf, the next step in the MAPK/ERK pathway. GTPase HRas is involved in regulating cell division in response to growth factor stimulation. Growth factors act by binding cell surface receptors that span the cell's plasma membrane. Once activated, receptors stimulate signal transduction events in the cytoplasm, a process by which proteins and second messengers relay signals from outside the cell to the cell nucleus and instructs the cell to grow or divide. The HRAS protein is a GTPase and is an early player in many signal transduction pathways and is usually associated with cell membranes due to the presence of an isoprenyl group on its C-terminus. HRAS acts as a molecular on/off switch, once it is turned on it recruits and activates proteins necessary for the propagation of the receptor's signal, such as c-Raf and PI 3-kinase. HRAS binds to GTP in the active state and possesses an intrinsic enzymatic activity that cleaves the terminal phosphate of this nucleotide converting it to GDP. Upon conversion of GTP to GDP, HRAS is turned off. The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein (GAP) class, for example RasGAP. In turn HRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example SOS1, which forces the release of bound nucleotide. Subsequently, GTP present in the cytosol binds and HRAS-GTP dissociates from the GEF, resulting in HRAS activation. HRAS is in the Ras family, which also includes two other proto-oncogenes: KRAS and NRAS. These proteins all are regulated in the same manner and appear to differ largely in their sites of action within the cell. (From Wiki)
 

===Cys Function & Property===
Cys118 is used to bind with GTP. 

* Hydrophobic property:
:[[File:508-hydro.png||600px]]
* SASA：
:Cys118: 270148 A^2 
:Cys184: Unknown 

==Protein Sequence==

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET 
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI 
KRVKDSDDVP MVLVGNK'''C'''DL AARTVESRQA QDLARSYGIP YIETSAKTRQ 
GVEDAFYTLV REIRQHKLRK LNPPDESGPG CMS'''C'''KCVLS 


==Structural Information==
*Known structure with covalent ligand: 
:[https://www.rcsb.org/structure/4US0 4US0], [https://www.rcsb.org/structure/4US1 4US1], [https://www.rcsb.org/structure/4US2 4US2] 

*Protein structure:
::[[File:508.png||800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko01521 EGFR tyrosine kinase inhibitor resistance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko01522 Endocrine resistance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04010 MAPK signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04012 ErbB signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04014 Ras signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04015 Rap1 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04062 Chemokine signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04068 FoxO signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04071 Sphingolipid signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04072 Phospholipase D signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04137 Mitophagy - animal] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04140 Autophagy - animal] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04144 Endocytosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04150 mTOR signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04151 PI3K-Akt signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04211 Longevity regulating pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04218 Cellular senescence] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04360 Axon guidance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04370 VEGF signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04371 Apelin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04540 Gap junction] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04550 Signaling pathways regulating pluripotency of stem cells] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04625 C-type lectin receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04630 Jak-STAT signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04650 Natural killer cell mediated cytotoxicity] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04660 T cell receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04662 B cell receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04664 Fc epsilon RI signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04714 Thermogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04720 Long-term potentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04722 Neurotrophin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04725 Cholinergic synapse] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04726 Serotonergic synapse] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04730 Long-term depression] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04810 Regulation of actin cytoskeleton] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04910 Insulin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04912 GnRH signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04915 Estrogen signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04916 Melanogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04917 Prolactin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04919 Thyroid hormone signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04921 Oxytocin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04926 Relaxin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04933 AGE-RAGE signaling pathway in diabetic complications] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05034 Alcoholism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05160 Hepatitis C] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05161 Hepatitis B] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05163 Human cytomegalovirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05165 Human papillomavirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05166 Human T-cell leukemia virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05167 Kaposi sarcoma-associated herpesvirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05170 Human immunodeficiency virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05200 Pathways in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05203 Viral carcinogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05205 Proteoglycans in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05206 MicroRNAs in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05210 Colorectal cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05211 Renal cell carcinoma] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05213 Endometrial cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05214 Glioma] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05215 Prostate cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05216 Thyroid cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05218 Melanoma] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05219 Bladder cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05220 Chronic myeloid leukemia] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05221 Acute myeloid leukemia] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05223 Non-small cell lung cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05224 Breast cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05225 Hepatocellular carcinoma] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05226 Gastric cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05230 Central carbon metabolism in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05231 Choline metabolism in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05235 PD-L1 expression and PD-1 checkpoint pathway in cancer] 

==Experimental Evidence==
:Crystallography, LC-ESI-MS/MS, Tryptic Digest, Cys-directed Mutation, Western Blot

==Reference==
# Oliva J L, Pérez-Sala D, Castrillo A, et al. '''The cyclopentenone 15-deoxy-Δ12,14-prostaglandin J2 binds to and activates H-Ras[J].''' Proceedings of the National Academy of Sciences, 2003, 100(8): 4772-4777. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12684535 12684535] 
# Springstead J R, Gugiu B G, Lee S, et al. '''Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function[J].''' Journal of lipid research, 2012, 53(7): 1304-1315. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22550136 22550136] 
# Sredni B, Geffen-Aricha R, Duan W, et al. '''Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson’s disease models[J].''' The FASEB Journal, 2007, 21(8): 1870-1883. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17314138 17314138] 
# Winter J J G, Anderson M, Blades K, et al. '''Small molecule binding sites on the Ras: SOS complex can be exploited for inhibition of Ras activation[J].''' Journal of medicinal chemistry, 2015, 58(5): 2265-2274. [https://www.ncbi.nlm.nih.gov/pubmed/?term=25695162 25695162] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:ATPase/GTPase|ATPase/GTPase]]
[[Category:Small GTPase superfamily|Small GTPase superfamily]]
[[Category:Ras family|Ras family]]
[[Category:EGFR tyrosine kinase inhibitor resistance|EGFR tyrosine kinase inhibitor resistance]]
[[Category:Endocrine resistance|Endocrine resistance]]
[[Category:MAPK signaling pathway|MAPK signaling pathway]]
[[Category:ErbB signaling pathway|ErbB signaling pathway]]
[[Category:Ras signaling pathway|Ras signaling pathway]]
[[Category:Rap1 signaling pathway|Rap1 signaling pathway]]
[[Category:Chemokine signaling pathway|Chemokine signaling pathway]]
[[Category:FoxO signaling pathway|FoxO signaling pathway]]
[[Category:Sphingolipid signaling pathway|Sphingolipid signaling pathway]]
[[Category:Sphingolipid signaling pathway|Sphingolipid signaling pathway]]
[[Category:Mitophagy - animal|Mitophagy - animal]]
[[Category:Autophagy - animal|Autophagy - animal]]
[[Category:Endocytosis|Endocytosis]]
[[Category:mTOR signaling pathway|mTOR signaling pathway]]
[[Category:PI3K-Akt signaling pathway|PI3K-Akt signaling pathway]]
[[Category:Apoptosis|Apoptosis]]
[[Category:Longevity regulating pathway|Longevity regulating pathway]]
[[Category:Cellular senescence|Cellular senescence]]
[[Category:Axon guidance|Axon guidance]]
[[Category:VEGF signaling pathway|VEGF signaling pathway]]
[[Category:Apelin signaling pathway|Apelin signaling pathway]]
[[Category:Gap junction|Gap junction]]
[[Category:Signaling pathways regulating pluripotency of stem cells|Signaling pathways regulating pluripotency of stem cells]]
[[Category:C-type lectin receptor signaling pathway|C-type lectin receptor signaling pathway]]
[[Category:Jak-STAT signaling pathway|Jak-STAT signaling pathway]]
[[Category:Natural killer cell mediated cytotoxicity|Natural killer cell mediated cytotoxicity]]
[[Category:T cell receptor signaling pathway|T cell receptor signaling pathway]]
[[Category:B cell receptor signaling pathway|B cell receptor signaling pathway]]
[[Category:Fc epsilon RI signaling pathway|Fc epsilon RI signaling pathway]]
[[Category:Thermogenesis|Thermogenesis]]
[[Category:Long-term potentiation|Long-term potentiation]]
[[Category:Neurotrophin signaling pathway|Neurotrophin signaling pathway]]
[[Category:Cholinergic synapse|Cholinergic synapse]]
[[Category:Serotonergic synapse|Serotonergic synapse]]
[[Category:Long-term depression|Long-term depression]]
[[Category:Regulation of actin cytoskeleton|Regulation of actin cytoskeleton]]
[[Category:Insulin signaling pathway|Insulin signaling pathway]]
[[Category:GnRH signaling pathway|GnRH signaling pathway]]
[[Category:Estrogen signaling pathway|Estrogen signaling pathway]]
[[Category:Melanogenesis|Melanogenesis]]
[[Category:Prolactin signaling pathway|Prolactin signaling pathway]]
[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
[[Category:Oxytocin signaling pathway|Oxytocin signaling pathway]]
[[Category:Relaxin signaling pathway|Relaxin signaling pathway]]
[[Category:AGE-RAGE signaling pathway in diabetic complications|AGE-RAGE signaling pathway in diabetic complications]]
[[Category:Alcoholism|Alcoholism]]
[[Category:Hepatitis C|Hepatitis C]]
[[Category:Hepatitis B|Hepatitis B]]
[[Category:Human cytomegalovirus infection|Human cytomegalovirus infection]]
[[Category:Human papillomavirus infection|Human papillomavirus infection]]
[[Category:Human T-cell leukemia virus 1 infection|Human T-cell leukemia virus 1 infection]]
[[Category:Kaposi sarcoma-associated herpesvirus infection|Kaposi sarcoma-associated herpesvirus infection]]
[[Category:Human immunodeficiency virus 1 infection|Human immunodeficiency virus 1 infection]]
[[Category:Pathways in cancer|Pathways in cancer]]
[[Category:Viral carcinogenesis|Viral carcinogenesis]]
[[Category:Proteoglycans in cancer|Proteoglycans in cancer]]
[[Category:MicroRNAs in cancer|MicroRNAs in cancer]]
[[Category:Colorectal cancer|Colorectal cancer]]
[[Category:Renal cell carcinoma|Renal cell carcinoma]]
[[Category:Endometrial cancer|Endometrial cancer]]
[[Category:Glioma|Glioma]]
[[Category:Prostate cancer|Prostate cancer]]
[[Category:Thyroid cancer|Thyroid cancer]]
[[Category:Melanoma|Melanoma]]
[[Category:Bladder cancer|Bladder cancer]]
[[Category:Chronic myeloid leukemia|Chronic myeloid leukemia]]
[[Category:Acute myeloid leukemia|Acute myeloid leukemia]]
[[Category:Non-small cell lung cancer|Non-small cell lung cancer]]
[[Category:Breast cancer|Breast cancer]]
[[Category:Hepatocellular carcinoma|Hepatocellular carcinoma]]
[[Category:Gastric cancer|Gastric cancer]]
[[Category:Central carbon metabolism in cancer|Central carbon metabolism in cancer]]
[[Category:Choline metabolism in cancer|Choline metabolism in cancer]]
[[Category:PD-L1 expression and PD-1 checkpoint pathway in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer]]

@@ Line 119: / Line 119: @@
 # Winter J J G, Anderson M, Blades K, et al. '''Small molecule binding sites on the Ras: SOS complex can be exploited for inhibition of Ras activation[J].''' Journal of medicinal chemistry, 2015, 58(5): 2265-2274. [https://www.ncbi.nlm.nih.gov/pubmed/?term=25695162 25695162]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:ATPase/GTPase|ATPase/GTPase]]
+[[Category:ATPase/GTPase]]
-[[Category:Small GTPase superfamily|Small GTPase superfamily]]
+[[Category:Small GTPase superfamily]]
-[[Category:Ras family|Ras family]]
+[[Category:Ras family]]
-[[Category:EGFR tyrosine kinase inhibitor resistance|EGFR tyrosine kinase inhibitor resistance]]
+[[Category:EGFR tyrosine kinase inhibitor resistance]]
-[[Category:Endocrine resistance|Endocrine resistance]]
+[[Category:Endocrine resistance]]
-[[Category:MAPK signaling pathway|MAPK signaling pathway]]
+[[Category:MAPK signaling pathway]]
-[[Category:ErbB signaling pathway|ErbB signaling pathway]]
+[[Category:ErbB signaling pathway]]
-[[Category:Ras signaling pathway|Ras signaling pathway]]
+[[Category:Ras signaling pathway]]
-[[Category:Rap1 signaling pathway|Rap1 signaling pathway]]
+[[Category:Rap1 signaling pathway]]
-[[Category:Chemokine signaling pathway|Chemokine signaling pathway]]
+[[Category:Chemokine signaling pathway]]
-[[Category:FoxO signaling pathway|FoxO signaling pathway]]
+[[Category:FoxO signaling pathway]]
-[[Category:Sphingolipid signaling pathway|Sphingolipid signaling pathway]]
+[[Category:Sphingolipid signaling pathway]]
-[[Category:Sphingolipid signaling pathway|Sphingolipid signaling pathway]]
+[[Category:Sphingolipid signaling pathway]]
-[[Category:Mitophagy - animal|Mitophagy - animal]]
+[[Category:Mitophagy - animal]]
-[[Category:Autophagy - animal|Autophagy - animal]]
+[[Category:Autophagy - animal]]
-[[Category:Endocytosis|Endocytosis]]
+[[Category:Endocytosis]]
-[[Category:mTOR signaling pathway|mTOR signaling pathway]]
+[[Category:mTOR signaling pathway]]
-[[Category:PI3K-Akt signaling pathway|PI3K-Akt signaling pathway]]
+[[Category:PI3K-Akt signaling pathway]]
-[[Category:Apoptosis|Apoptosis]]
+[[Category:Apoptosis]]
-[[Category:Longevity regulating pathway|Longevity regulating pathway]]
+[[Category:Longevity regulating pathway]]
-[[Category:Cellular senescence|Cellular senescence]]
+[[Category:Cellular senescence]]
-[[Category:Axon guidance|Axon guidance]]
+[[Category:Axon guidance]]
-[[Category:VEGF signaling pathway|VEGF signaling pathway]]
+[[Category:VEGF signaling pathway]]
-[[Category:Apelin signaling pathway|Apelin signaling pathway]]
+[[Category:Apelin signaling pathway]]
-[[Category:Gap junction|Gap junction]]
+[[Category:Gap junction]]
-[[Category:Signaling pathways regulating pluripotency of stem cells|Signaling pathways regulating pluripotency of stem cells]]
+[[Category:Signaling pathways regulating pluripotency of stem cells]]
-[[Category:C-type lectin receptor signaling pathway|C-type lectin receptor signaling pathway]]
+[[Category:C-type lectin receptor signaling pathway]]
-[[Category:Jak-STAT signaling pathway|Jak-STAT signaling pathway]]
+[[Category:Jak-STAT signaling pathway]]
-[[Category:Natural killer cell mediated cytotoxicity|Natural killer cell mediated cytotoxicity]]
+[[Category:Natural killer cell mediated cytotoxicity]]
-[[Category:T cell receptor signaling pathway|T cell receptor signaling pathway]]
+[[Category:T cell receptor signaling pathway]]
-[[Category:B cell receptor signaling pathway|B cell receptor signaling pathway]]
+[[Category:B cell receptor signaling pathway]]
-[[Category:Fc epsilon RI signaling pathway|Fc epsilon RI signaling pathway]]
+[[Category:Fc epsilon RI signaling pathway]]
-[[Category:Thermogenesis|Thermogenesis]]
+[[Category:Thermogenesis]]
-[[Category:Long-term potentiation|Long-term potentiation]]
+[[Category:Long-term potentiation]]
-[[Category:Neurotrophin signaling pathway|Neurotrophin signaling pathway]]
+[[Category:Neurotrophin signaling pathway]]
-[[Category:Cholinergic synapse|Cholinergic synapse]]
+[[Category:Cholinergic synapse]]
-[[Category:Serotonergic synapse|Serotonergic synapse]]
+[[Category:Serotonergic synapse]]
-[[Category:Long-term depression|Long-term depression]]
+[[Category:Long-term depression]]
-[[Category:Regulation of actin cytoskeleton|Regulation of actin cytoskeleton]]
+[[Category:Regulation of actin cytoskeleton]]
-[[Category:Insulin signaling pathway|Insulin signaling pathway]]
+[[Category:Insulin signaling pathway]]
-[[Category:GnRH signaling pathway|GnRH signaling pathway]]
+[[Category:GnRH signaling pathway]]
-[[Category:Estrogen signaling pathway|Estrogen signaling pathway]]
+[[Category:Estrogen signaling pathway]]
-[[Category:Melanogenesis|Melanogenesis]]
+[[Category:Melanogenesis]]
-[[Category:Prolactin signaling pathway|Prolactin signaling pathway]]
+[[Category:Prolactin signaling pathway]]
-[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
+[[Category:Thyroid hormone signaling pathway]]
-[[Category:Oxytocin signaling pathway|Oxytocin signaling pathway]]
+[[Category:Oxytocin signaling pathway]]
-[[Category:Relaxin signaling pathway|Relaxin signaling pathway]]
+[[Category:Relaxin signaling pathway]]
-[[Category:AGE-RAGE signaling pathway in diabetic complications|AGE-RAGE signaling pathway in diabetic complications]]
+[[Category:AGE-RAGE signaling pathway in diabetic complications]]
-[[Category:Alcoholism|Alcoholism]]
+[[Category:Alcoholism]]
-[[Category:Hepatitis C|Hepatitis C]]
+[[Category:Hepatitis C]]
-[[Category:Hepatitis B|Hepatitis B]]
+[[Category:Hepatitis B]]
-[[Category:Human cytomegalovirus infection|Human cytomegalovirus infection]]
+[[Category:Human cytomegalovirus infection]]
-[[Category:Human papillomavirus infection|Human papillomavirus infection]]
+[[Category:Human papillomavirus infection]]
-[[Category:Human T-cell leukemia virus 1 infection|Human T-cell leukemia virus 1 infection]]
+[[Category:Human T-cell leukemia virus 1 infection]]
-[[Category:Kaposi sarcoma-associated herpesvirus infection|Kaposi sarcoma-associated herpesvirus infection]]
+[[Category:Kaposi sarcoma-associated herpesvirus infection]]
-[[Category:Human immunodeficiency virus 1 infection|Human immunodeficiency virus 1 infection]]
+[[Category:Human immunodeficiency virus 1 infection]]
-[[Category:Pathways in cancer|Pathways in cancer]]
+[[Category:Pathways in cancer]]
-[[Category:Viral carcinogenesis|Viral carcinogenesis]]
+[[Category:Viral carcinogenesis]]
-[[Category:Proteoglycans in cancer|Proteoglycans in cancer]]
+[[Category:Proteoglycans in cancer]]
-[[Category:MicroRNAs in cancer|MicroRNAs in cancer]]
+[[Category:MicroRNAs in cancer]]
-[[Category:Colorectal cancer|Colorectal cancer]]
+[[Category:Colorectal cancer]]
-[[Category:Renal cell carcinoma|Renal cell carcinoma]]
+[[Category:Renal cell carcinoma]]
-[[Category:Endometrial cancer|Endometrial cancer]]
+[[Category:Endometrial cancer]]
-[[Category:Glioma|Glioma]]
+[[Category:Glioma]]
-[[Category:Prostate cancer|Prostate cancer]]
+[[Category:Prostate cancer]]
-[[Category:Thyroid cancer|Thyroid cancer]]
+[[Category:Thyroid cancer]]
-[[Category:Melanoma|Melanoma]]
+[[Category:Melanoma]]
-[[Category:Bladder cancer|Bladder cancer]]
+[[Category:Bladder cancer]]
-[[Category:Chronic myeloid leukemia|Chronic myeloid leukemia]]
+[[Category:Chronic myeloid leukemia]]
-[[Category:Acute myeloid leukemia|Acute myeloid leukemia]]
+[[Category:Acute myeloid leukemia]]
-[[Category:Non-small cell lung cancer|Non-small cell lung cancer]]
+[[Category:Non-small cell lung cancer]]
-[[Category:Breast cancer|Breast cancer]]
+[[Category:Breast cancer]]
-[[Category:Hepatocellular carcinoma|Hepatocellular carcinoma]]
+[[Category:Hepatocellular carcinoma]]
-[[Category:Gastric cancer|Gastric cancer]]
+[[Category:Gastric cancer]]
-[[Category:Central carbon metabolism in cancer|Central carbon metabolism in cancer]]
+[[Category:Central carbon metabolism in cancer]]
-[[Category:Choline metabolism in cancer|Choline metabolism in cancer]]
+[[Category:Choline metabolism in cancer]]
-[[Category:PD-L1 expression and PD-1 checkpoint pathway in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer]]
+[[Category:PD-L1 expression and PD-1 checkpoint pathway in cancer]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|[http://pfam.xfam.org/family/PF00071 Ras family],<br/>Small GTPase superfamily|[[:Category:GTPase HRas|Ligand list]]|ATPase/GTPase}}
+{{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|Small GTPase superfamily,<br/>[http://pfam.xfam.org/family/PF00071 Ras family]|[[:Category:GTPase HRas|Ligand list]]|ATPase/GTPase}}
 ==Summary==

@@ Line 16: / Line 16: @@
 :[[File:508-hydro.png||600px]]
 * SASA：
-:Cys118: 270148 A^2<br/>
+:Cys118: 27.148 A^2<br/>
 :Cys184: Unknown<br/>

@@ Line 11: / Line 11: @@
 ===Cys Function & Property===
-Cys118 is used to bind with GTP. <br/>
+Cys118 is used to bind with GTP in HRas. <br/>
 * Hydrophobic property:

@@ Line 32: / Line 32: @@
 *Protein structure:
-::[[File:508.png||800px]]
+::[[File:508.png|center|800px]]
 ==Related Pathway==

GTPase HRas - Revision history

Wu3857: /* Reference */

Wu3857 at 02:59, 10 August 2019

Wu3857: /* Cys Function & Property */

Wu3857: /* Structural Information */

Wu3857: /* Cys Function & Property */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|[http://pfam.xfam.org/..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|HRAS, p21ras|[https://www.uniprot.org/uniprot/P01112 P01112]|Homo sapiens|Cys118, Cys184|[http://pfam.xfam.org/..."