GMP synthetase - Revision history

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2019-08-19T22:59:47Z

‎Reference

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‎Protein Function

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‎Protein Function

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‎Protein Function

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‎Protein Function

Wu3857: /* Summary */

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‎Summary

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‎Protein Function

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‎Protein Function

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‎Protein Function

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 # Nakamura J, Straub K, Wu J, et al. '''The Glutamine Hydrolysis Function of Human GMP Synthetase Identification of an essential active site cysteine[J].''' Journal of Biological Chemistry, 1995, 270(40): 23450-23455. [https://www.ncbi.nlm.nih.gov/pubmed/?term=7559506 7559506]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Metabolic enzyme|Metabolic enzyme]]
+[[Category:Metabolic enzyme]]
-[[Category:Glutamine amidotransferase|Glutamine amidotransferase]]
+[[Category:Glutamine amidotransferase]]
-[[Category:Purine metabolism|Purine metabolism]]
+[[Category:Purine metabolism]]
-[[Category:Drug metabolism - other enzymes|Drug metabolism - other enzymes]]
+[[Category:Drug metabolism - other enzymes]]
-[[Category:Metabolic pathways|Metabolic pathways]]
+[[Category:Metabolic pathways]]

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 In enzymology, a GMP synthetase (glutamine-hydrolysing) is an enzyme that catalyzes the chemical reaction:<br/>
 <div align="left">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font size="4">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
-The four substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.<br/>
+The four substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its four products are AMP, diphosphate, GMP, and L-glutamate.<br/>
 This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in purine metabolism and glutamate metabolism. At least one compound, Psicofuranin is known to inhibit this enzyme. (From Wiki)
 <br/>

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 Guanosine monophosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.<br/>
 In enzymology, a GMP synthetase (glutamine-hydrolysing) is an enzyme that catalyzes the chemical reaction:<br/>
-<div align="center">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font size="4">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
+<div align="left">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font size="4">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
 The four substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.<br/>
 This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in purine metabolism and glutamate metabolism. At least one compound, Psicofuranin is known to inhibit this enzyme. (From Wiki)

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 Guanosine monophosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.<br/>
 In enzymology, a GMP synthetase (glutamine-hydrolysing) is an enzyme that catalyzes the chemical reaction:<br/>
-<div align="center">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font size="3">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
+<div align="center">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font size="4">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
 The four substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.<br/>
 This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in purine metabolism and glutamate metabolism. At least one compound, Psicofuranin is known to inhibit this enzyme. (From Wiki)

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 Guanosine monophosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.<br/>
 In enzymology, a GMP synthetase (glutamine-hydrolysing) is an enzyme that catalyzes the chemical reaction:<br/>
-<div align="center">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font siez="3">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
+<div align="center">ATP + xanthosine 5'-phosphate + L-glutamine + H2O <font size="3">'''↔'''</font> AMP + diphosphate + GMP + L-glutamate</div>
 The four substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.<br/>
 This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in purine metabolism and glutamate metabolism. At least one compound, Psicofuranin is known to inhibit this enzyme. (From Wiki)

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 Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. (From Uniprot)<br/>
 Guanosine monophosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.<br/>
-In enzymology, a GMP synthetase (glutamine-hydrolysing) (EC 6.3.5.2) is an enzyme that catalyzes the chemical reaction<br/>
+In enzymology, a GMP synthetase (glutamine-hydrolysing) is an enzyme that catalyzes the chemical reaction:<br/>
 ATP + xanthosine 5'-phosphate + L-glutamine + H2O AMP + diphosphate + GMP + L-glutamate<br/>
 The 4 substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.<br/>