Estrogen receptor - Revision history

Wu3857: /* Reference */

2019-08-19T22:19:14Z

‎Reference

Wu3857 at 21:00, 19 August 2019

2019-08-19T21:00:34Z

Wu3857 at 20:59, 19 August 2019

2019-08-19T20:59:04Z

Wu3857: /* Reference */

2019-08-19T20:58:16Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|VDR, NR1I1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/fa..."

2019-08-19T20:56:53Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|VDR, NR1I1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/fa..."

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{| align="left"
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{{#invoke:InfoboxforTarget|run|VDR, NR1I1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/family/PF00104 Ligand-binding domain of nuclear hormone receptor], Nuclear hormone receptor family, NR3 subfamily|[[:Category:Estrogen receptor|Ligand list]]|Transcription Related, Metabolic enzyme}}
==Summary==

===Protein Function ===
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. (From Uniprot) 

===Cys Function & Property===
Cys288 is very close to the active site of VDR in space. 

* Hydrophobic property:
:[[File:575-hydro.png||600px]]
* SASA:
:Cys417: 55.382 A^2 
:Cys530: 73.207 A^2 

==Protein Sequence==

MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA 
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL 
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY 
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW 
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM 
MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR 
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA 
DRELVHMINW AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG 
KLLFAPNLLL DRNQGK'''C'''VEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS 
IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ 
HQRLAQLLLI LSHIRHMSNK GMEHLYSMK'''C''' KNVVPLYDLL LEMLDAHRLH 
APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:[[File:575.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko01522 Endocrine resistance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04915 Estrogen signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04917 Prolactin signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04919 Thyroid hormone signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04961 Endocrine and other factor-regulated calcium reabsorption] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05200 Pathways in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05205 Proteoglycans in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05224 Breast cancer] 

==Experimental Evidence==
:Cys-directed Mutation

==Reference==
# Aliau S, El Garrouj D, Yasri A, et al. '''17α-(Haloacetamidoalkyl) estradiols alkylate the human estrogen receptor at cysteine residues 417 and 530[J].''' Biochemistry, 1997, 36(19): 5861-5867. [https://www.ncbi.nlm.nih.gov/pubmed/?term=9153427 9153427] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Transcription Related|Transcription Related]]
[[Category:Metabolic enzyme|Metabolic enzyme]]
[[Category:Nuclear hormone receptor family|Nuclear hormone receptor family]]
[[Category:NR3 subfamily|NR3 subfamily]]
[[Category:Endocrine resistance|Endocrine resistance]]
[[Category:Estrogen signaling pathway|Estrogen signaling pathway]]
[[Category:Prolactin signaling pathway|Prolactin signaling pathway]]
[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
[[Category:Endocrine and other factor-regulated calcium reabsorption|Endocrine and other factor-regulated calcium reabsorption]]
[[Category:Pathways in cancer|Pathways in cancer]]
[[Category:Proteoglycans in cancer|Proteoglycans in cancer]]
[[Category:PBreast cancer|Breast cancer]]

@@ Line 55: / Line 55: @@
 # Aliau S, El Garrouj D, Yasri A, et al. '''17α-(Haloacetamidoalkyl) estradiols alkylate the human estrogen receptor at cysteine residues 417 and 530[J].''' Biochemistry, 1997, 36(19): 5861-5867. [https://www.ncbi.nlm.nih.gov/pubmed/?term=9153427 9153427]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Transcription Related|Transcription Related]]
+[[Category:Transcription Related]]
-[[Category:Metabolic enzyme|Metabolic enzyme]]
+[[Category:Metabolic enzyme]]
-[[Category:Nuclear hormone receptor family|Nuclear hormone receptor family]]
+[[Category:Nuclear hormone receptor family]]
-[[Category:NR3 subfamily|NR3 subfamily]]
+[[Category:NR3 subfamily]]
-[[Category:Endocrine resistance|Endocrine resistance]]
+[[Category:Endocrine resistance]]
-[[Category:Estrogen signaling pathway|Estrogen signaling pathway]]
+[[Category:Estrogen signaling pathway]]
-[[Category:Prolactin signaling pathway|Prolactin signaling pathway]]
+[[Category:Prolactin signaling pathway]]
-[[Category:Thyroid hormone signaling pathway|Thyroid hormone signaling pathway]]
+[[Category:Thyroid hormone signaling pathway]]
-[[Category:Endocrine and other factor-regulated calcium reabsorption|Endocrine and other factor-regulated calcium reabsorption]]
+[[Category:Endocrine and other factor-regulated calcium reabsorption]]
-[[Category:Pathways in cancer|Pathways in cancer]]
+[[Category:Pathways in cancer]]
-[[Category:Proteoglycans in cancer|Proteoglycans in cancer]]
+[[Category:Proteoglycans in cancer]]
-[[Category:Breast cancer|Breast cancer]]
+[[Category:Breast cancer]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|VDR, NR1I1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/family/PF00104 Ligand-binding domain of nuclear hormone receptor],<br/>Nuclear hormone receptor family,<br/>NR3 subfamily|[[:Category:Estrogen receptor|Ligand list]]|Transcription Related, Metabolic enzyme}}
+{{#invoke:InfoboxforTarget|run|ESR1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/family/PF00104 Ligand-binding domain of nuclear hormone receptor],<br/>Nuclear hormone receptor family,<br/>NR3 subfamily|[[:Category:Estrogen receptor|Ligand list]]|Transcription Related, Metabolic enzyme}}
 ==Summary==

@@ Line 9: / Line 9: @@
 ===Cys Function & Property===
 * Hydrophobic property:
 :[[File:575-hydro.png||600px]]

Estrogen receptor - Revision history

Wu3857: /* Reference */

Wu3857 at 21:00, 19 August 2019

Wu3857 at 20:59, 19 August 2019

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|VDR, NR1I1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/fa..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|VDR, NR1I1|[https://www.uniprot.org/uniprot/P11473 P11473]|Homo sapiens|Cys417, Cys530|[http://pfam.xfam.org/fa..."