Cysteinome:About - Revision history

Wu3857 at 03:01, 30 September 2023

2023-09-30T03:01:02Z

Wu3857 at 03:00, 30 September 2023

2023-09-30T03:00:26Z

Wu3857 at 14:48, 10 January 2021

2021-01-10T14:48:16Z

Wu3857 at 14:45, 10 January 2021

2021-01-10T14:45:28Z

Wu3857 at 14:41, 10 January 2021

2021-01-10T14:41:16Z

Wu3857 at 18:36, 21 January 2020

2020-01-21T18:36:12Z

Wu3857 at 18:35, 21 January 2020

2020-01-21T18:35:46Z

Wu3857 at 05:58, 21 January 2020

2020-01-21T05:58:34Z

Wu3857 at 05:58, 21 January 2020

2020-01-21T05:58:24Z

Wu3857 at 05:58, 21 January 2020

2020-01-21T05:58:18Z

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 '''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu.<br/>
-:'''Sijin Wu''', Ph.D. , Professor (Assistant) at Xi'an Jiaotong-Liverpool University (Email: sijin.wu84 AT gmail.com).<br/>
+:'''Sijin Wu''', Ph.D. , Professor (Assistant) at Academy of Pharmacy, Xi'an Jiaotong-Liverpool University (Email: sijin.wu84 AT gmail.com).<br/>
 :'''Yongliang Yang''', Ph.D. , Professor at Center for Molecular Medicine, School of Life Science and Biotechnology, DLUT (Email: everbright99 AT gmail.com).

@@ Line 8: / Line 8: @@
 '''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu.<br/>
-:'''Sijin Wu''', Ph.D. , Associate professor at Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Email: sijin.wu84 AT gmail.com).<br/>
+:'''Sijin Wu''', Ph.D. , Professor (Assistant) at Xi'an Jiaotong-Liverpool University (Email: sijin.wu84 AT gmail.com).<br/>
-:'''Yongliang Yang''', Ph.D. , Associate professor at Center for Molecular Medicine, School of Life Science and Biotechnology, DLUT (Email: everbright99 AT gmail.com).
+:'''Yongliang Yang''', Ph.D. , Professor at Center for Molecular Medicine, School of Life Science and Biotechnology, DLUT (Email: everbright99 AT gmail.com).

@@ Line 6: / Line 6: @@
 ==Developers==
-'''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu at Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.<br/>
+'''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu.<br/>
 :'''Sijin Wu''', Ph.D. , Associate professor at Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Email: sijin.wu84 AT gmail.com).<br/>
 :'''Yongliang Yang''', Ph.D. , Associate professor at Center for Molecular Medicine, School of Life Science and Biotechnology, DLUT (Email: everbright99 AT gmail.com).

@@ Line 8: / Line 8: @@
 '''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu at Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.<br/>
-:'''Sijin Wu''', Ph.D. , Postdoctoral researcher at Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, OSU (Email: wu.3857 AT osu.edu).<br/>
+:'''Sijin Wu''', Ph.D. , Associate professor at Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Email: sijin.wu84 AT gmail.com).<br/>
 :'''Yongliang Yang''', Ph.D. , Associate professor at Center for Molecular Medicine, School of Life Science and Biotechnology, DLUT (Email: everbright99 AT gmail.com).

@@ Line 6: / Line 6: @@
 ==Developers==
-'''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu at College of Pharmacy, The Ohio State University, USA.<br/>
+'''Cysteinome''' is developed by Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, China, and now maintained by Sijin Wu at Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.<br/>
 :'''Sijin Wu''', Ph.D. , Postdoctoral researcher at Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, OSU (Email: wu.3857 AT osu.edu).<br/>
 :'''Yongliang Yang''', Ph.D. , Associate professor at Center for Molecular Medicine, School of Life Science and Biotechnology, DLUT (Email: everbright99 AT gmail.com).

@@ Line 1: / Line 1: @@
 The covalent modification of intrinsically nucleophilic cysteine in proteins is crucial for diverse biochemical events. Bioinformatics approaches may prove useful in the design and discovery of covalent molecules targeting the cysteine in proteins to tune their functions and activities. <br/>
-'''Cysteinome''', the first online database that provides a rich resource for the display, search and analysis of structure, function and related annotation for proteins with targetable cysteine as well as their covalent modulators. It compiles over '''400 proteins''' with targetable cysteine along with more than '''1200 covalent modulators''' curated from existing literatures. Proteins are annotated with a detailed description of protein families, biological process and related diseases. In addition, covalent modulators are carefully annotated with chemical name, chemical structure, binding affinity, physicochemical properties, molecule type and related diseases etc.<br/>
+'''Cysteinome''', the first online database that provides a rich resource for the display, search and analysis of structure, function and related annotation for proteins with targetable cysteine as well as their covalent modulators. In this database it compiles over '''400 proteins''' with targetable cysteine along with more than '''1200 covalent modulators''' curated from existing literatures. Proteins are annotated with a detailed description of protein families, biological process and related diseases. In addition, covalent modulators are carefully annotated with chemical name, chemical structure, binding affinity, physicochemical properties, molecule type and related diseases etc.<br/>
 The Cysteinome database serve as a useful platform for the identification of crucial proteins with targetable cysteine in certain cellular context. Furthermore, it may help biologists and chemists for the design and discovery of covalent chemical probes or inhibitors homing at functional cysteine of critical protein targets implicated in various physiological or disease process.<br/>

← Older revision		Revision as of 05:58, 21 January 2020
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−	<font size="4">The covalent modification of intrinsically nucleophilic cysteine in proteins is crucial for diverse biochemical events. Bioinformatics approaches may prove useful in the design and discovery of covalent molecules targeting the cysteine in proteins to tune their functions and activities. <br/>	+	<font size="2">The covalent modification of intrinsically nucleophilic cysteine in proteins is crucial for diverse biochemical events. Bioinformatics approaches may prove useful in the design and discovery of covalent molecules targeting the cysteine in proteins to tune their functions and activities. <br/>

	'''Cysteinome''', the first online database that provides a rich resource for the display, search and analysis of structure, function and related annotation for proteins with targetable cysteine as well as their covalent modulators. It compiles over '''400''' proteins with targetable cysteine along with more than '''1200''' covalent modulators curated from existing literatures. Proteins are annotated with a detailed description of protein families, biological process and related diseases. In addition, covalent modulators are carefully annotated with chemical name, chemical structure, binding affinity, physicochemical properties, molecule type and related diseases etc.<br/>		'''Cysteinome''', the first online database that provides a rich resource for the display, search and analysis of structure, function and related annotation for proteins with targetable cysteine as well as their covalent modulators. It compiles over '''400''' proteins with targetable cysteine along with more than '''1200''' covalent modulators curated from existing literatures. Proteins are annotated with a detailed description of protein families, biological process and related diseases. In addition, covalent modulators are carefully annotated with chemical name, chemical structure, binding affinity, physicochemical properties, molecule type and related diseases etc.<br/>