Cofilin-1 - Revision history

Wu3857: /* Reference */

2019-08-19T22:06:43Z

‎Reference

Wu3857 at 03:25, 8 August 2019

2019-08-08T03:25:35Z

Wu3857 at 03:21, 8 August 2019

2019-08-08T03:21:04Z

Wu3857 at 03:19, 8 August 2019

2019-08-08T03:19:26Z

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Cofilin-1, p18|[https://www.uniprot.org/uniprot/P23528 P23528]|Homo sapiens|Cys139|[http://pfam.xfam.org/family..."

2019-08-08T03:06:23Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Cofilin-1, p18|[https://www.uniprot.org/uniprot/P23528 P23528]|Homo sapiens|Cys139|[http://pfam.xfam.org/family..."

New page

{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|Cofilin-1, p18|[https://www.uniprot.org/uniprot/P23528 P23528]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00241 Cofilin/tropomyosin-type actin-binding protein], Actin-binding proteins ADF family]|[[:Category:Cofilin-1|Ligand list]]|Structural protein}}

==Summary==

===Protein Function ===
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. 
One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration. 

===Cys Function & Property===
Both Cys234 and Cys179 are located within the first catalytic cysteine domain (FCCH) of E1, a subdomain conserved in human E1 that spans from residues 175–265 and forms one wall of a broad deep groove unique to eukaryotic E1. The rat Cys234 location is identical to that reported for human E1 in vitro whereas the modified Cys179 on rat E1 represents an additional modification. 

* Hydrophobic property:
:[[File:540-hydro.png||600px]]
* SASA：
:Cys139: 36.275 A^2

==Protein Sequence==

MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE 
EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV 
FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANMASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE 
EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV 
FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA 
EKLGGSAVIS LEGKPL 


==Structural Information==
*Known structures with covalent ligands: 
:Unknown 

*Protein structure:
[[File:540.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04360 Axon guidance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04666 Fc gamma R-mediated phagocytosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04810 Regulation of actin cytoskeleton] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05133 Pertussis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05170 Human immunodeficiency virus 1 infection] 

==Experimental Evidence==
:Mass Spectrometry, Tryptic Digest

==Reference==
# Gabrielsen M, Schuldt M, Munro J, et al. '''Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target[J].''' Cell Communication and Signaling, 2013, 11(1): 58. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23945128 23945128] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Structural protein|Structural protein]]
[[Category:Actin-binding proteins ADF family|Actin-binding proteins ADF family]]
[[Category:Fc gamma R-mediated phagocytosis|Fc gamma R-mediated phagocytosis]]
[[Category:Regulation of actin cytoskeleton|Regulation of actin cytoskeleton]]
[[Category:Pertussis|Pertussis]]
[[Category:Human immunodeficiency virus 1 infection|Human immunodeficiency virus 1 infection]]

@@ Line 46: / Line 46: @@
 # Gabrielsen M, Schuldt M, Munro J, et al. '''Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target[J].''' Cell Communication and Signaling, 2013, 11(1): 58. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23945128 23945128]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Structural protein|Structural protein]]
+[[Category:Structural protein]]
-[[Category:Actin-binding proteins ADF family|Actin-binding proteins ADF family]]
+[[Category:Actin-binding proteins ADF family]]
-[[Category:Fc gamma R-mediated phagocytosis|Fc gamma R-mediated phagocytosis]]
+[[Category:Fc gamma R-mediated phagocytosis]]
-[[Category:Regulation of actin cytoskeleton|Regulation of actin cytoskeleton]]
+[[Category:Regulation of actin cytoskeleton]]
-[[Category:Pertussis|Pertussis]]
+[[Category:Pertussis]]
-[[Category:Human immunodeficiency virus 1 infection|Human immunodeficiency virus 1 infection]]
+[[Category:Human immunodeficiency virus 1 infection]]

@@ Line 11: / Line 11: @@
 ===Cys Function & Property===
-Both Cys234 and Cys179 are located within the first catalytic cysteine domain (FCCH) of E1, a subdomain conserved in human E1 that spans from residues 175–265 and forms one wall of a broad deep groove unique to eukaryotic E1. The rat Cys234 location is identical to that reported for human E1 in vitro whereas the modified Cys179 on rat E1 represents an additional modification.<br/>
+Molecules covalent bind with Cys139 would disrupt the interface between Cofilin1 and actin.<br/>
 * Hydrophobic property:

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|Cofilin-1, p18|[https://www.uniprot.org/uniprot/P23528 P23528]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00241 Cofilin/tropomyosin-type actin-binding protein],<br/>Actin-binding proteins ADF family]|[[:Category:Cofilin-1|Ligand list]]|Structural protein}}
+{{#invoke:InfoboxforTarget|run|Cofilin-1, p18|[https://www.uniprot.org/uniprot/P23528 P23528]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00241 Cofilin/tropomyosin-type actin-binding protein],<br/>Actin-binding proteins ADF family|[[:Category:Cofilin-1|Ligand list]]|Structural protein}}
 ==Summary==