Cathepsin S - Revision history

Wu3857: /* Reference */

2019-08-19T21:54:06Z

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Wu3857 at 20:36, 29 July 2019

2019-07-29T20:36:46Z

Wu3857: /* Reference */

2019-07-28T20:24:45Z

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Wu3857: /* Structural Information */

2019-07-28T18:18:28Z

‎Structural Information

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2019-07-28T04:24:20Z

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2019-07-28T03:52:07Z

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Wu3857: /* Structural Information */

2019-07-28T03:49:57Z

‎Structural Information

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 P..."

2019-07-28T03:49:42Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 P..."

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{| align="left"
| __TOC__
|}
{{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin S|Ligand list]]}}
==Summary==

===Protein Function ===
Cathepsin S is a thiol protease, which act as key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. (From Uniprot)
 

===Cys Function & Property===
Cys139 is one of the active sites of Cathepsin S, which is very close to His278 and Asn298 in space. These three residues formed a typical catalytic triad motif. 

* Hydrophobic property:
:[[File:486-hydro.png||600px]]
* SASA：
:Cys139: 11.884 A^2

==Protein Sequence==

MKRLVCVLLV CSSAVAQLHK DPTLDHHWHL WKKTYGKQYK EKNEEAVRRL 
IWEKNLKFVM LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPSQ 
WQRNITYKSN PNRILPDSVD WREKGCVTEV KYQGSCGA'''C'''W AFSAVGALEA 
QLKLKTGKLV SLSAQNLVDC STEKYGNKGC NGGFMTTAFQ YIIDNKGIDS 
DASYPYKAMD QKCQYDSKYR AATCSKYTEL PYGREDVLKE AVANKGPVSV 
GVDARHPSFF LYRSGVYYEP SCTQNVNHGV LVVGYGDLNG KEYWLVKNSW 
GHNFGEEGYI RMARNKGNHC GIASFPSYPE I 


==Structural Information==
*Known structures with covalent ligands: 
:[https://www.rcsb.org/structure/1NPZ 1NPZ], [https://www.rcsb.org/structure/3N4C 3N4C], [https://www.rcsb.org/structure/2OP3 2OP3] 

*Protein structure
[[File:486.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04145 Phagosome] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05152 Tuberculosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04612 Antigen processing and presentation] 

==Experimental Evidence==
:Crystallography, Cys-directed mutation, Homologous Analysis of Sequence, Enzymatic Assay

==Reference==
# Pauly T A, Sulea T, Ammirati M, et al. '''Specificity determinants of human cathepsin S revealed by crystal structures of complexes[J].''' Biochemistry, 2003, 42(11): 3203-3213. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12641451 12641451] 
# Cai J, Baugh M, Black D, et al. '''6-Phenyl-1H-imidazo [4, 5-c] pyridine-4-carbonitrile as cathepsin S inhibitors[J].''' Bioorganic & medicinal chemistry letters, 2010, 20(15): 4350-4354. [https://www.ncbi.nlm.nih.gov/pubmed/?term=20598883 20598883] 
# Inagaki H, Tsuruoka H, Hornsby M, et al. '''Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode[J].''' Journal of medicinal chemistry, 2007, 50(11): 2693-2699. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17469812 17469812] 
# Bekkali Y, Thomson D S, Betageri R, et al. '''Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J].''' Bioorganic & medicinal chemistry letters, 2007, 17(9): 2465-2469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17379516 17379516] 

[[Category:Targets|Targets]]
[[Category:Peptidase C1 family|Peptidase C1 family]]
[[Category:Phagosome|Phagosome]]
[[Category:Tuberculosis|Tuberculosis]]
[[Category:Antigen processing and presentation|Antigen processing and presentation]]

@@ Line 49: / Line 49: @@
 # Bekkali Y, Thomson D S, Betageri R, et al. '''Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J].''' Bioorganic & Medicinal Chemistry Letters, 2007, 17(9): 2465-2469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17379516 17379516]<br/>
 [[Category:Targets]]
 [[Category:Homo sapiens]]
-[[Category:Targets|Targets]]
+[[Category:Protease]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Peptidase C1 family]]
-[[Category:Protease|Protease]]
+[[Category:Lysosome]]
-[[Category:Peptidase C1 family|Peptidase C1 family]]
+[[Category:Phagosome]]
-[[Category:Lysosome|Lysosome]]
+[[Category:Tuberculosis]]
-[[Category:Phagosome|Phagosome]]
+[[Category:Antigen processing and presentation]]

@@ Line 31: / Line 31: @@
 *Known structures with covalent ligands: <br/>
 :[https://www.rcsb.org/structure/1NPZ 1NPZ], [https://www.rcsb.org/structure/3N4C 3N4C], [https://www.rcsb.org/structure/2OP3 2OP3]<br/>
-*Protein structure
+*Protein structure:
 [[File:486.png|center|800px]]

@@ Line 45: / Line 45: @@
 ==Reference==
 # Pauly T A, Sulea T, Ammirati M, et al. '''Specificity determinants of human cathepsin S revealed by crystal structures of complexes[J].''' Biochemistry, 2003, 42(11): 3203-3213. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12641451 12641451]<br/>
-# Cai J, Baugh M, Black D, et al. '''6-Phenyl-1H-imidazo [4, 5-c] pyridine-4-carbonitrile as cathepsin S inhibitors[J].''' Bioorganic & medicinal chemistry letters, 2010, 20(15): 4350-4354. [https://www.ncbi.nlm.nih.gov/pubmed/?term=20598883 20598883]<br/>
+# Cai J, Baugh M, Black D, et al. '''6-Phenyl-1H-imidazo [4, 5-c] pyridine-4-carbonitrile as cathepsin S inhibitors[J].''' Bioorganic & Medicinal Chemistry Letters, 2010, 20(15): 4350-4354. [https://www.ncbi.nlm.nih.gov/pubmed/?term=20598883 20598883]<br/>
-# Inagaki H, Tsuruoka H, Hornsby M, et al. '''Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode[J].''' Journal of medicinal chemistry, 2007, 50(11): 2693-2699. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17469812 17469812]<br/>
+# Inagaki H, Tsuruoka H, Hornsby M, et al. '''Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode[J].''' Journal of Medicinal Chemistry, 2007, 50(11): 2693-2699. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17469812 17469812]<br/>
-# Bekkali Y, Thomson D S, Betageri R, et al. '''Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J].''' Bioorganic & medicinal chemistry letters, 2007, 17(9): 2465-2469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17379516 17379516]<br/>
+# Bekkali Y, Thomson D S, Betageri R, et al. '''Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J].''' Bioorganic & Medicinal Chemistry Letters, 2007, 17(9): 2465-2469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17379516 17379516]<br/>

@@ Line 31: / Line 31: @@
 *Known structures with covalent ligands: <br/>
 :[https://www.rcsb.org/structure/1NPZ 1NPZ], [https://www.rcsb.org/structure/3N4C 3N4C], [https://www.rcsb.org/structure/2OP3 2OP3]<br/>
 *Protein structure
 [[File:486.png|center|800px]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin S|Ligand list]]}}
+{{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin S|Ligand list]]|Protease}}
 ==Summary==
@@ Line 53: / Line 53: @@
 [[Category:Targets|Targets]]
 [[Category:Homo sapiens|Homo sapiens]]
 [[Category:Peptidase C1 family|Peptidase C1 family]]
 [[Category:Lysosome|Lysosome]]

Cathepsin S - Revision history

Wu3857: /* Reference */

Wu3857 at 20:36, 29 July 2019

Wu3857: /* Reference */

Wu3857: /* Structural Information */

Wu3857: /* Reference */

Wu3857: /* Reference */

Wu3857: /* Structural Information */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 P..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CTSS|[https://www.uniprot.org/uniprot/P25774 P25774]|Homo sapiens|Cys139|[http://pfam.xfam.org/family/PF00112 P..."