Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CTSK|[https://www.uniprot.org/uniprot/P43236 P43236]|Oryctolagus cuniculus|Cys139|[http://pfam.xfam.org/family/..."

2019-12-05T04:31:22Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CTSK|[https://www.uniprot.org/uniprot/P43236 P43236]|Oryctolagus cuniculus|Cys139|[http://pfam.xfam.org/family/..."

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{{#invoke:InfoboxforTarget|run|CTSK|[https://www.uniprot.org/uniprot/P43236 P43236]|Oryctolagus cuniculus|Cys139|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin K (Oryctolagus cuniculus)|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Cathepsin K, a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts. The enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism. Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury. (From Wikipedia)
 

===Cys Function & Property===
Cys139 is one of the active sites of Cathepsin K, which is very close to His276 and Asn296 in space (By similiarity). These three residues formed a typical catalytic triad motif. 

* Hydrophobic property:
:[[File:591-hydro.png||600px]]
* SASA:
:Cys139: 11.628 A^2 

==Protein Sequence==

MWGLKVLLLP VVSFALHPEE ILDTQWELWK KTYSKQYNSK VDEISRRLIW 
EKNLKHISIH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLKVPPSRS 
HSNDTLYIPD WEGRTPDSID YRKKGYVTPV KNQGQCGS'''C'''W AFSSVGALEG 
QLKKKTGKLL NLSPQNLVDC VSENYGCGGG YMTNAFQYVQ RNRGIDSEDA 
YPYVGQDESC MYNPTGKAAK CRGYREIPEG NEKALKRAVA RVGPVSVAID 
ASLTSFQFYS KGVYYDENCS SDNVNHAVLA VGYGIQKGNK HWIIKNSWGE 
SWGNKGYILM ARNKNNACGI ANLASFPKM 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
[[File:591.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04380 Osteoclast differentiation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04620 Toll-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05323 Rheumatoid arthritis] 

==Experimental Evidence==
:Homologous Analysis Of Sequence, Isotope Labeling

==Reference==
# Falgueyret J P, Black W C, Cromlish W, et al. '''An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells[J].''' Analytical biochemistry, 2004, 335(2): 218-227. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15556560 15556560 ] 
# Barrett D G, Catalano J G, Deaton D N, et al. '''Potent and selective P2–P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1′, P1, and/or P3 substitutions[J].''' Bioorganic & medicinal chemistry letters, 2004, 14(19): 4897-4902. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15341947 15341947] 

[[Category:Targets]]
[[Category:Oryctolagus cuniculus]]
[[Category:Protease]]
[[Category:Peptidase C1 family]]
[[Category:Apoptosis]]
[[Category:Lysosome]]
[[Category:Osteoclast differentiation]]
[[Category:Toll-like receptor signaling pathway]]
[[Category:Rheumatoid arthritis]]

Cathepsin K (Oryctolagus cuniculus) - Revision history

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CTSK|[https://www.uniprot.org/uniprot/P43236 P43236]|Oryctolagus cuniculus|Cys139|[http://pfam.xfam.org/family/..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CTSK|[https://www.uniprot.org/uniprot/P43236 P43236]|Oryctolagus cuniculus|Cys139|[http://pfam.xfam.org/family/..."