Wu3857: /* Reference */

2019-08-19T21:48:44Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CSPB, CTSB|[https://www.uniprot.org/uniprot/P00787 P00787]|Rattus norvegicus|Cys108|[http://pfam.xfam.org/famil..."

2019-07-31T18:45:42Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CSPB, CTSB|[https://www.uniprot.org/uniprot/P00787 P00787]|Rattus norvegicus|Cys108|[http://pfam.xfam.org/famil..."

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{{#invoke:InfoboxforTarget|run|CSPB, CTSB|[https://www.uniprot.org/uniprot/P00787 P00787]|Rattus norvegicus|Cys108|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin B (Rattus norvegicus)|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. (From Uniprot) 
Cathepsin B (CatB) is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. (From Wikipedia)
 

===Cys Function & Property===
Cys108 is one of the active sites of Cathepsin B, which is very close to His278 and Asn298 in space. These three residues formed a typical catalytic triad motif. 

* Hydrophobic property:
:[[File:510-hydro.png||600px]]
* SASA：
:Cys108: 4.025 A^2 

==Protein Sequence==

MWWSLIPLSC LLALTSAHDK PSSHPLSDDM INYINKQNTT WQAGRNFYNV 
DISYLKKLCG TVLGGPNLPE RVGFSEDINL PESFDAREQW SNCPTIAQIR 
DQGSCGS'''C'''WA FGAVEAMSDR ICIHTNGRVN VEVSAEDLLT CCGIQCGDGC 
NGGYPSGAWN FWTRKGLVSG GVYNSHIGCL PYTIPPCEHH VNGSRPPCTG 
EGDTPKCNKM CEAGYSTSYK EDKHYGYTSY SVSDSEKEIM AEIYKNGPVE 
GAFTVFSDFL TYKSGVYKHE AGDVMGGHAI RILGWGIENG VPYWLVANSW 
NVDWGDNGFF KILRGENHCG IESEIVAGIP RTQQYWGRF 


==Structural Information==
*Known structure with covalent ligand: 
:[https://www.rcsb.org/structure/1THE 1THE], [https://www.rcsb.org/structure/1CTE 1CTE] 

*Protein structure:
::[[File:510.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04140 Autophagy - animal] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04612 Antigen processing and presentation] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04621 NOD-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04924 Renin secretion] 

==Experimental Evidence==
:Crystallography

==Reference==
# Jia Z, Hasnain S, Hirama T, et al. '''Crystal Structures of Recombinant Rat Cathepsin B and a Cathepsin B-Inhibitor Complex IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN[J].''' Journal of Biological Chemistry, 1995, 270(10): 5527-5533. [https://www.ncbi.nlm.nih.gov/pubmed/?term=7890671 7890671] 

[[Category:Targets|Targets]]
[[Category:Rattus norvegicus|Rattus norvegicus]]
[[Category:Protease|Protease]]
[[Category:Peptidase C1 family|Peptidase C1 family]]
[[Category:Autophagy - animal|Autophagy - animal]]
[[Category:Lysosome|Lysosome]]
[[Category:Apoptosis|Apoptosis]]
[[Category:Antigen processing and presentation|Antigen processing and presentation]]
[[Category: NOD-like receptor signaling pathway| NOD-like receptor signaling pathway]]
[[Category:Renin secretion|Renin secretion]]

@@ Line 50: / Line 50: @@
 # Jia Z, Hasnain S, Hirama T, et al. '''Crystal Structures of Recombinant Rat Cathepsin B and a Cathepsin B-Inhibitor Complex IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN[J].''' Journal of Biological Chemistry, 1995, 270(10): 5527-5533. [https://www.ncbi.nlm.nih.gov/pubmed/?term=7890671 7890671]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Rattus norvegicus|Rattus norvegicus]]
+[[Category:Rattus norvegicus]]
-[[Category:Protease|Protease]]
+[[Category:Protease]]
-[[Category:Peptidase C1 family|Peptidase C1 family]]
+[[Category:Peptidase C1 family]]
-[[Category:Autophagy - animal|Autophagy - animal]]
+[[Category:Autophagy - animal]]
-[[Category:Lysosome|Lysosome]]
+[[Category:Lysosome]]
-[[Category:Apoptosis|Apoptosis]]
+[[Category:Apoptosis]]
-[[Category:Antigen processing and presentation|Antigen processing and presentation]]
+[[Category:Antigen processing and presentation]]
-[[Category: NOD-like receptor signaling pathway| NOD-like receptor signaling pathway]]
+[[Category: NOD-like receptor signaling pathway]]
-[[Category:Renin secretion|Renin secretion]]
+[[Category:Renin secretion]]

Cathepsin B (Rattus norvegicus) - Revision history

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CSPB, CTSB|[https://www.uniprot.org/uniprot/P00787 P00787]|Rattus norvegicus|Cys108|[http://pfam.xfam.org/famil..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CSPB, CTSB|[https://www.uniprot.org/uniprot/P00787 P00787]|Rattus norvegicus|Cys108|[http://pfam.xfam.org/famil..."