Cathepsin B (Bos taurus) - Revision history

Wu3857: /* Reference */

2019-08-19T21:45:13Z

‎Reference

Wu3857: /* Reference */

2019-08-01T15:08:02Z

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Wu3857: /* Reference */

2019-08-01T15:07:22Z

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Wu3857 at 20:34, 29 July 2019

2019-07-29T20:34:25Z

Wu3857 at 20:29, 29 July 2019

2019-07-29T20:29:01Z

Wu3857 at 20:34, 28 July 2019

2019-07-28T20:34:45Z

Wu3857 at 20:33, 28 July 2019

2019-07-28T20:33:15Z

Wu3857: /* Structural Information */

2019-07-28T18:18:00Z

‎Structural Information

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2019-07-28T03:16:33Z

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@@ Line 54: / Line 54: @@
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Bos taurus|Bos taurus]]
+[[Category:Bos taurus]]
-[[Category:Protease|Protease]]
+[[Category:Protease]]
-[[Category:Peptidase C1 family|Peptidase C1 family]]
+[[Category:Peptidase C1 family]]
-[[Category:Lysosome|Lysosome]]
+[[Category:Lysosome]]
-[[Category:Antigen processing and presentation|Antigen processing and presentation]]
+[[Category:Antigen processing and presentation]]
-[[Category:Autophagy - animal|Autophagy - animal]]
+[[Category:Autophagy - animal]]
-[[Category:Apoptosis|Apoptosis]]
+[[Category:Apoptosis]]
-[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
+[[Category:NOD-like receptor signaling pathway]]
-[[Category:Renin secretion|Renin secretion]]
+[[Category:Renin secretion]]

@@ Line 60: / Line 60: @@
 [[Category:Lysosome|Lysosome]]
 [[Category:Antigen processing and presentation|Antigen processing and presentation]]
-[[Category:Autophagy|Autophagy - animal]]
+[[Category:Autophagy - animal|Autophagy - animal]]
 [[Category:Apoptosis|Apoptosis]]
 [[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
 [[Category:Renin secretion|Renin secretion]]

@@ Line 60: / Line 60: @@
 [[Category:Lysosome|Lysosome]]
 [[Category:Antigen processing and presentation|Antigen processing and presentation]]
-[[Category:Autophagy|Autophagy]]
+[[Category:Autophagy|Autophagy - animal]]
 [[Category:Apoptosis|Apoptosis]]
 [[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
 [[Category:Renin secretion|Renin secretion]]

@@ Line 56: / Line 56: @@
 [[Category:Targets|Targets]]
 [[Category:Bos taurus|Bos taurus]]
-{{Category:Protease|Protease]]
+[[Category:Protease|Protease]]
 [[Category:Peptidase C1 family|Peptidase C1 family]]
 [[Category:Lysosome|Lysosome]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|CTSB|[https://www.uniprot.org/uniprot/P07688 P07688]|Bos taurus|Cys108|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin B (Bos taurus)|Ligand list]]}}
+{{#invoke:InfoboxforTarget|run|CTSB|[https://www.uniprot.org/uniprot/P07688 P07688]|Bos taurus|Cys108|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Cathepsin B (Bos taurus)|Ligand list]]|Protease}}
 ==Summary==
@@ Line 56: / Line 56: @@
 [[Category:Targets|Targets]]
 [[Category:Bos taurus|Bos taurus]]
 [[Category:Peptidase C1 family|Peptidase C1 family]]
 [[Category:Lysosome|Lysosome]]

← Older revision		Revision as of 20:34, 28 July 2019
Line 59:		Line 59:
	[[Category:Lysosome\|Lysosome]]		[[Category:Lysosome\|Lysosome]]
	[[Category:Antigen processing and presentation\|Antigen processing and presentation]]		[[Category:Antigen processing and presentation\|Antigen processing and presentation]]
		+	[[Category:Autophagy\|Autophagy]]
		+	[[Category:Apoptosis\|Apoptosis]]
		+	[[Category:NOD-like receptor signaling pathway\|NOD-like receptor signaling pathway]]
		+	[[Category:Renin secretion\|Renin secretion]]

@@ Line 38: / Line 38: @@
 *[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] <br/>
 *[https://www.genome.jp/kegg-bin/show_pathway?ko04612 Antigen processing and presentation]<br/>
 ==Experimental Evidence==
@@ Line 51: / Line 55: @@
 [[Category:Targets|Targets]]
 [[Category:Peptidase C1 family|Peptidase C1 family]]
 [[Category:Lysosome|Lysosome]]
 [[Category:Antigen processing and presentation|Antigen processing and presentation]]

@@ Line 32: / Line 32: @@
 :[https://www.rcsb.org/structure/1QDQ 1QDQ], [https://www.rcsb.org/structure/1ITO 1ITO], [https://www.rcsb.org/structure/1SP4 1SP4], [https://www.rcsb.org/structure/2DC6 2DC6]<br/>
-*Protein structure
+*Protein structure:
 [[File:483.PNG|center|800px]]

@@ Line 43: / Line 43: @@
 ==Reference==
-# Yamamoto A, Tomoo K, Hara T, et al. '''Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex[J].''' The Journal of Biochemistry, 2000, 127(4): 635-643 [https://www.ncbi.nlm.nih.gov/pubmed/?term=10739956 10739956]<br/>
+# Yamamoto A, Tomoo K, Hara T, et al. '''Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex[J].''' The Journal of Biochemistry, 2000, 127(4): 635-643. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10739956 10739956]<br/>
 # Smith R A, Copp L J, Coles P J, et al. '''New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy[J].''' Journal of the American Chemical Society, 1988, 110(13): 4429-4431. DOI: 10.1021/ja00221a062 <br/>
 # Štern I, Schaschke N, Moroder L, et al. '''Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft[J].''' Biochemical Journal, 2004, 381(2): 511-517. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15084146 15084146]<br/>

@@ Line 45: / Line 45: @@
 # Yamamoto A, Tomoo K, Hara T, et al. '''Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex[J].''' The Journal of Biochemistry, 2000, 127(4): 635-643 [https://www.ncbi.nlm.nih.gov/pubmed/?term=10739956 10739956]<br/>
 # Smith R A, Copp L J, Coles P J, et al. '''New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy[J].''' Journal of the American Chemical Society, 1988, 110(13): 4429-4431. DOI: 10.1021/ja00221a062 <br/>
-# Štern I, Schaschke N, Moroder L, et al. '''Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft[J].''' Biochemical Journal, 2004, 381(2): 511-517.[https://www.ncbi.nlm.nih.gov/pubmed/?term=15084146 15084146]<br/>
+# Štern I, Schaschke N, Moroder L, et al. '''Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft[J].''' Biochemical Journal, 2004, 381(2): 511-517. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15084146 15084146]<br/>
 # Yamamoto A, Tomoo K, Matsugi K, et al. '''Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B–E64c complex[J].''' Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology, 2002, 1597(2): 244-251. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12044902 12044902]<br/>
 # Watanabe D, Yamamoto A, Tomoo K, et al. '''Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity–binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes[J].''' Journal of molecular biology, 2006, 362(5): 979-993. [https://www.ncbi.nlm.nih.gov/pubmed/?term=16950396 16950396]<br/>