Caspase-6 - Revision history

Wu3857: /* Protein Function */

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‎Protein Function

Wu3857: /* Summary */

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‎Summary

Wu3857: /* Summary */

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‎Summary

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{{#invoke:InfoboxforTarget|run|CASP6|[https://www.uniprot.org/uniprot/P55212 P55212]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656 Peptidase C14A family]|[[:Category:Caspase-6|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Caspase-6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases-7, -8 and -10, and is thought to function as a downstream enzyme in the caspase activation cascade. Caspase-6 can also undergo self-processing without other members of the caspase family. Alternative splicing of this gene results in two transcript variants that encode different isoforms. (From Wikipedia)
 

===Cys Function & Property===
The catalytic triad in Caspase-6 comprises Cys163, His121 and Arg64. 

* Hydrophobic property:
:[[File:597-hydro.png||600px]]
* SASA:
:Cys163: 60.255 A^2 

==Protein Sequence==

MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF 
NHERFFWHLT LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI 
HEVSTVSHAD ADCFVCVFLS HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS 
LVGKPKIFII QA'''C'''RGNQHDV PVIPLDVVDN QTEKLDTNIT EVDAASVYTL 
PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG SSLEFTELLT 
LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN 


==Structural Information==
*Known structure with covalent ligand: 
:[https://www.rcsb.org/structure/3P4U 3P4U] 
:[https://www.rcsb.org/structure/3QNW 3QNW] 
:[https://www.rcsb.org/structure/3S70 3S70] 

*Protein structure:
[[File:597.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 

==Experimental Evidence==
:Crystallography, Site-directed mutation assasy

==Reference==
# Müller I, Lamers M B A C, Ritchie A J, et al. '''Structure of human caspase-6 in complex with Z-VAD-FMK: new peptide binding mode observed for the non-canonical caspase conformation[J].''' Bioorganic & medicinal chemistry letters, 2011, 21(18): 5244-5247. [https://www.ncbi.nlm.nih.gov/pubmed/?term=21820899 21820899] 
# Liu X, Zhang H, Wang X J, et al. '''Get phases from arsenic anomalous scattering: de novo SAD phasing of two protein structures crystallized in cacodylate buffer[J].''' PLoS One, 2011, 6(9): e24227. [https://www.ncbi.nlm.nih.gov/pubmed/?term=21912678 21912678] 

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Protease]]
[[Category:Peptidase C14A family]]
[[Category:Apoptosis]]

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 ===Protein Function ===
 Caspase-6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases-7, -8 and -10, and is thought to function as a downstream enzyme in the caspase activation cascade. <br/>
 Caspase-6 can also undergo self-processing without other members of the caspase family. Alternative splicing of this gene results in two transcript variants that encode different isoforms. (From Wikipedia)
 <br/>
 ===Cys Function & Property===

Caspase-6 - Revision history

Wu3857: /* Protein Function */

Wu3857: /* Summary */

Wu3857: /* Summary */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CASP6|[https://www.uniprot.org/uniprot/P55212 P55212]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CASP6|[https://www.uniprot.org/uniprot/P55212 P55212]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656..."