Caspase-5 - Revision history

Wu3857: /* Protein Function */

2020-01-04T05:42:43Z

‎Protein Function

Wu3857: /* Cys Function & Property */

2020-01-04T05:42:34Z

‎Cys Function & Property

Wu3857 at 05:42, 4 January 2020

2020-01-04T05:42:21Z

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CASP5|[https://www.uniprot.org/uniprot/P51878 P51878]|Homo sapiens|Cys315|[http://pfam.xfam.org/family/PF00656..."

2020-01-04T05:41:07Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CASP5|[https://www.uniprot.org/uniprot/P51878 P51878]|Homo sapiens|Cys315|[http://pfam.xfam.org/family/PF00656..."

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{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|CASP5|[https://www.uniprot.org/uniprot/P51878 P51878]|Homo sapiens|Cys315|[http://pfam.xfam.org/family/PF00656 Peptidase C14A family]|[[:Category:Caspase-5|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Caspase-5 is a member of the cysteine-aspartic acid protease (caspase) family. It is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. It is an inflammatory caspase, along with caspase-1, caspase-4 and the murine caspase-4 homolog caspase-11, and has a role in the immune system. (From Wikipedia, PMID: 22014003) 

===Cys Function & Property===
The catalytic triad in Caspase-5 comprises Cys315, His267 and Arg221 by similarity. 

* Hydrophobic property:
:[[File:596-hydro.png||600px]]
* SASA:
:Cys315: Unknown 

==Protein Sequence==

MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP 
NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK 
KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE 
AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN 
TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA 
RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC 
LSLKDKPKVI IVQA'''C'''RGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK 
IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF 
RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:Unknown 

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04621 NOD-like receptor signaling pathway] 

==Experimental Evidence==
:Similarity, Site-directed mutation assasy

==Reference==
# Gao J, Wells J A. '''Identification of specific tethered inhibitors for caspase‐5[J].''' Chemical biology & drug design, 2012, 79(2): 209-215. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22014003 22014003] 

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Protease]]
[[Category:Peptidase C14A family]]
[[Category:NOD-like receptor signaling pathway]]

@@ Line 7: / Line 7: @@
 ===Protein Function ===
 Caspase-5 is a member of the cysteine-aspartic acid protease (caspase) family. It is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue y (preferred cleavage after Trp-GluXaa-Asp).<br/>
 It is an inflammatory caspase, along with caspase-1, caspase-4 and the murine caspase-4 homolog caspase-11, and has a role in the immune system. (From Wikipedia, PMID: 22014003) <br/>
 ===Cys Function & Property===

@@ Line 10: / Line 10: @@
 ===Cys Function & Property===
-The catalytic triad in Caspase-5 comprises Cys315, His267 and Arg221 by similarity. <br/>
+The catalytic triad in Caspase-5 comprises Cys315, His267 and Arg221 by similarity. <br/><br/>
 * Hydrophobic property:

@@ Line 6: / Line 6: @@
 ===Protein Function ===
-Caspase-5 is a member of the cysteine-aspartic acid protease (caspase) family. It is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. It is an inflammatory caspase, along with caspase-1, caspase-4 and the murine caspase-4 homolog caspase-11, and has a role in the immune system. (From Wikipedia, PMID: 22014003) <br/>
+Caspase-5 is a member of the cysteine-aspartic acid protease (caspase) family. It is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue y (preferred cleavage after Trp-GluXaa-Asp).<br/>
 ===Cys Function & Property===

Caspase-5 - Revision history

Wu3857: /* Protein Function */

Wu3857: /* Cys Function & Property */

Wu3857 at 05:42, 4 January 2020

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CASP5|[https://www.uniprot.org/uniprot/P51878 P51878]|Homo sapiens|Cys315|[http://pfam.xfam.org/family/PF00656..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CASP5|[https://www.uniprot.org/uniprot/P51878 P51878]|Homo sapiens|Cys315|[http://pfam.xfam.org/family/PF00656..."