Wu3857 at 05:15, 4 January 2020

2020-01-04T05:15:34Z

Wu3857: /* Cys Function & Property */

2020-01-04T05:15:15Z

‎Cys Function & Property

Wu3857: /* Reference */

2020-01-04T05:14:23Z

‎Reference

Wu3857: /* Reference */

2020-01-04T05:14:03Z

‎Reference

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CASP3|[https://www.uniprot.org/uniprot/P42574 P42574]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656..."

2020-01-04T05:13:04Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CASP3|[https://www.uniprot.org/uniprot/P42574 P42574]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656..."

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{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|CASP3|[https://www.uniprot.org/uniprot/P42574 P42574]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656 Peptidase C14A family]|[[:Category:Caspase-3|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Caspases (cysteine-aspartic acid protease (Caspase) family) are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Activation of Caspases ensures that the cellular components are degraded in a controlled manner, carrying out cell death with minimal effect on surrounding tissues. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of Caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. 

===Cys Function & Property===
The catalytic triad in Caspase-3 comprises Cys163, His121 and the backbone carbonyl oxygen atom of Arg64, which points towards the Nϵ atom of His121. 

* Hydrophobic property:
:[[File:594-hydro.png||600px]]
* SASA:
:Cys163: 7.11 A^2 

==Protein Sequence==

MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII 
NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM 
RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS 
LTGKPKLFII QA'''C'''RGTELDC GIETDSGVDD DMACHKIPVE ADFLYAYSTA 
PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN RKVATEFESF 
SFDATFHAKK QIPCIVSMLT KELYFYH 


==Structural Information==
*Known structure with covalent ligand: 
:[https://www.rcsb.org/structure/1PAU 1PAU] 
:[https://www.rcsb.org/structure/1NME 1NME] 
:[https://www.rcsb.org/structure/1NMQ 1NMQ] 
:[https://www.rcsb.org/structure/1NMS 1NMS] 

*Protein structure:
[[File:594.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko01524 Platinum drug resistance] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04010 MAPK signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04115 p53 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04650 Natural killer cell mediated cytotoxicity] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04657 IL-17 signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04668 TNF signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04726 Serotonergic synapse] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04932 Non-alcoholic fatty liver disease (NAFLD)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04933 AGE-RAGE signaling pathway in diabetic complications] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05010 Alzheimer disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05012 Parkinson disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05014 Amyotrophic lateral sclerosis (ALS)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05016 Huntington disease] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05120 Epithelial cell signaling in Helicobacter pylori infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05130 Pathogenic Escherichia coli infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05133 Pertussis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05134 Legionellosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05145 Toxoplasmosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05146 Amoebiasis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05152 Tuberculosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05160 Hepatitis C] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05161 Hepatitis B] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05162 Measles] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05163 Human cytomegalovirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05164 Influenza A] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05165 Human papillomavirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05167 Kaposi sarcoma-associated herpesvirus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05168 Herpes simplex virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05169 Epstein-Barr virus infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05170 Human immunodeficiency virus 1 infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05200 Pathways in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05203 Viral carcinogenesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05205 Proteoglycans in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05206 MicroRNAs in cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05210 Colorectal cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05222 Small cell lung cancer] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05416 Viral myocarditis] 

==Experimental Evidence==
:Crystallography

==Reference==
# Y Wei, T Fox, S P Chambers et al. '''The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.''' Chem Biol, 2000, 7(6): 423-432. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10873833 10873833] 
# Erlanson D A, Lam J W, Wiesmann C, et al. '''In situ assembly of enzyme inhibitors using extended tethering[J].''' Nature biotechnology, 2003, 21(3): 308. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12563278 12563278] 

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Protease]]
[[Category:Peptidase C14A family]]
[[Category:Platinum drug resistance]]
[[Category:MAPK signaling pathway]]
[[Category:p53 signaling pathway]]
[[Category:Apoptosis]]
[[Category:Apoptosis - multiple species]]
[[Category:Natural killer cell mediated cytotoxicity]]
[[Category:IL-17 signaling pathway]]
[[Category:TNF signaling pathway]]
[[Category:Serotonergic synapse]]
[[Category:Non-alcoholic fatty liver disease (NAFLD)]]
[[Category:AGE-RAGE signaling pathway in diabetic complications]]
[[Category:Alzheimer disease]]
[[Category:Parkinson disease]]
[[Category:Amyotrophic lateral sclerosis (ALS)]]
[[Category:Huntington disease]]
[[Category:Epithelial cell signaling in Helicobacter pylori infection]]
[[Category:Pathogenic Escherichia coli infection]]
[[Category:Pertussis]]
[[Category:Legionellosis]]
[[Category:Toxoplasmosis]]
[[Category:Amoebiasis]]
[[Category:Tuberculosis]]
[[Category:Hepatitis C]]
[[Category:Hepatitis B]]
[[Category:Measles]]
[[Category:Human cytomegalovirus infection]]
[[Category:Influenza A]]
[[Category:Human papillomavirus infection]]
[[Category:Kaposi sarcoma-associated herpesvirus infection]]
[[Category:Herpes simplex virus 1 infection]]
[[Category:Epstein-Barr virus infection]]
[[Category:Human immunodeficiency virus 1 infection]]
[[Category:Pathways in cancer]]
[[Category:Viral carcinogenesis]]
[[Category:Proteoglycans in cancer]]
[[Category:MicroRNAs in cancer]]
[[Category:Colorectal cancer]]
[[Category:Small cell lung cancer]]
[[Category:Viral myocarditis]]

@@ Line 6: / Line 6: @@
 ===Protein Function ===
-Caspases (cysteine-aspartic acid protease (Caspase) family) are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Activation of Caspases ensures that the cellular components are degraded in a controlled manner, carrying out cell death with minimal effect on surrounding tissues. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of Caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. <br/>
+Caspases (cysteine-aspartic acid protease (Caspase) family) are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Activation of Caspases ensures that the cellular components are degraded in a controlled manner, carrying out cell death with minimal effect on surrounding tissues. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of Caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. <br/> <br/>
 ===Cys Function & Property===

@@ Line 9: / Line 9: @@
 ===Cys Function & Property===
-The catalytic triad in Caspase-3 comprises Cys163, His121 and the backbone carbonyl oxygen atom of Arg64, which points towards the Nϵ atom of His121.<br/>
+The catalytic triad in Caspase-3 comprises Cys163, His121 and the backbone carbonyl oxygen atom of Arg64, which points towards the Nϵ atom of His121.<br/><br/>
 * Hydrophobic property:

@@ Line 82: / Line 82: @@
 ==Reference==
-# Y Wei, T Fox, S P Chambers et al. '''The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.''' Chem Biol, 2000, 7(6): 423-432. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10873833 10873833]<br/>
+# Y Wei, T Fox, S P Chambers et al. '''The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity[J].''' Chem Biol, 2000, 7(6): 423-432. [https://www.ncbi.nlm.nih.gov/pubmed/?term=10873833 10873833]<br/>
 # Erlanson D A, Lam J W, Wiesmann C, et al. '''In situ assembly of enzyme inhibitors using extended tethering[J].''' Nature biotechnology, 2003, 21(3): 308. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12563278 12563278]<br/>

@@ Line 93: / Line 93: @@
 [[Category:p53 signaling pathway]]
 [[Category:Apoptosis]]
 [[Category:Natural killer cell mediated cytotoxicity]]
 [[Category:IL-17 signaling pathway]]

Caspase-3 - Revision history

Wu3857 at 05:15, 4 January 2020

Wu3857: /* Cys Function & Property */

Wu3857: /* Reference */

Wu3857: /* Reference */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CASP3|[https://www.uniprot.org/uniprot/P42574 P42574]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CASP3|[https://www.uniprot.org/uniprot/P42574 P42574]|Homo sapiens|Cys163|[http://pfam.xfam.org/family/PF00656..."