Caspase-1 - Revision history

Wu3857 at 02:16, 4 December 2019

2019-12-04T02:16:14Z

Wu3857: /* Reference */

2019-08-19T21:42:43Z

‎Reference

Wu3857 at 02:04, 19 August 2019

2019-08-19T02:04:46Z

Wu3857: /* Structural Information */

2019-08-18T19:17:49Z

‎Structural Information

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00619..."

2019-08-18T19:07:35Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00619..."

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{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00619 Caspase recruitment domain], Peptidase C14A family]|[[:Category:Caspase-1|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Caspase-1 (also known as interleukin 1β-converting enzyme or ICE) is expressed as a procaspase-1 zymogen that is processed into a catalytically competent form through autoproteolysis induced by protein oligomerization in vitro, but may require caspase-5 for efficient activation in vivo. It cleaves IL-1β between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Caspase-1 is important for defense against pathogens. It could cleaves and activates sterol regulatory element binding proteins (SREBPs). It also can promote apoptosis. (From Uniprot, PMID: 16511067) 

===Cys Function & Property===
Cys285 is one of the active sites of CASP-1. 

* Hydrophobic property:
:[[File:569-hydro.png||600px]]
* SASA：
:Cys285: 11.718 A^2 

==Protein Sequence==

MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV 
MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN 
MQDSQGVLSS FPAPQAVQDN PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA 
EIYPIMDKSS RTRLALIICN EEFDSIPRRT GAEVDITGMT MLLQNLGYSV 
DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR EGICGKKHSE 
QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQA'''C'''RGDSP GVVWFKDSVG 
VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI 
GRLIEHMQEY ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL 
FPGH 


==Structural Information==
*Known structure with covalent ligand: 
[https://www.rcsb.org/structure/1ICE 1ICE], [https://www.rcsb.org/structure/3NS7 3NS7], [https://www.rcsb.org/structure/1BMQ 1BMQ], [https://www.rcsb.org/structure/1RWK 1RWK], [https://www.rcsb.org/structure/1RWM 1RWM], [https://www.rcsb.org/structure/1RWN 1RWN], [https://www.rcsb.org/structure/1RWO 1RWO], [https://www.rcsb.org/structure/1RWP 1RWP], [https://www.rcsb.org/structure/1RWV 1RWV], [https://www.rcsb.org/structure/1RWW 1RWW], [https://www.rcsb.org/structure/1RWX 1RWX], [https://www.rcsb.org/structure/2H4W 2H4W], [https://www.rcsb.org/structure/2H4Y 2H4Y], [https://www.rcsb.org/structure/2H51 2H51], [https://www.rcsb.org/structure/2H54 2H54], [https://www.rcsb.org/structure/2HBQ 2HBQ], [https://www.rcsb.org/structure/2HBR 2HBR], [https://www.rcsb.org/structure/2HBY 2HBY], [https://www.rcsb.org/structure/2HBZ 2HBZ]

*Protein structure:
:[[File:569.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04217 Necroptosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04621 NOD-like receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04623 Cytosolic DNA-sensing pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko04625 C-type lectin receptor signaling pathway] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05014 Amyotrophic lateral sclerosis (ALS)] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05132 Salmonella infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05133 Pertussis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05134 Legionellosis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05135 Yersinia infection] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05164 Influenza A] 

==Experimental Evidence==
:Crystallography

==Reference==
# Lee J, Bogyo M. '''Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain[J].''' Bioorganic & medicinal chemistry letters, 2012, 22(3): 1340-1343. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22243962 22243962] 
# Dall E, Brandstetter H. '''Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation[J].''' Proceedings of the National Academy of Sciences, 2013, 110(27): 10940-10945. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23776206 23776206] 

[[Category:Targets|Targets]]
[[Category:Homo sapiens|Homo sapiens]]
[[Category:Protease|Protease]]
[[Category:Peptidase C14A family|Peptidase C14A family]]
[[Category:Necroptosis|Necroptosis]]
[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
[[Category:Cytosolic DNA-sensing pathway|Cytosolic DNA-sensing pathway]]
[[Category:C-type lectin receptor signaling pathway|C-type lectin receptor signaling pathway]]
[[Category:Amyotrophic lateral sclerosis (ALS)|Amyotrophic lateral sclerosis (ALS)]]
[[Category:Salmonella infection|Salmonella infection]]
[[Category:Pertussis|Pertussis]]
[[Category:Legionellosis|Legionellosis]]
[[Category:Yersinia infection|Yersinia infection]]
[[Category:Influenza A|Influenza A]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00619 Caspase recruitment domain],<br/>Peptidase C14A family|[[:Category:Caspase-1|Ligand list]]|Protease}}
+{{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00656 Peptidase C14A family]|[[:Category:Caspase-1|Ligand list]]|Protease}}
 ==Summary==

@@ Line 55: / Line 55: @@
 # Dall E, Brandstetter H. '''Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation[J].''' Proceedings of the National Academy of Sciences, 2013, 110(27): 10940-10945. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23776206 23776206]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Homo sapiens|Homo sapiens]]
+[[Category:Homo sapiens]]
-[[Category:Protease|Protease]]
+[[Category:Protease]]
-[[Category:Peptidase C14A family|Peptidase C14A family]]
+[[Category:Peptidase C14A family]]
-[[Category:Necroptosis|Necroptosis]]
+[[Category:Necroptosis]]
-[[Category:NOD-like receptor signaling pathway|NOD-like receptor signaling pathway]]
+[[Category:NOD-like receptor signaling pathway]]
-[[Category:Cytosolic DNA-sensing pathway|Cytosolic DNA-sensing pathway]]
+[[Category:Cytosolic DNA-sensing pathway]]
-[[Category:C-type lectin receptor signaling pathway|C-type lectin receptor signaling pathway]]
+[[Category:C-type lectin receptor signaling pathway]]
-[[Category:Amyotrophic lateral sclerosis (ALS)|Amyotrophic lateral sclerosis (ALS)]]
+[[Category:Amyotrophic lateral sclerosis (ALS)]]
-[[Category:Salmonella infection|Salmonella infection]]
+[[Category:Salmonella infection]]
-[[Category:Pertussis|Pertussis]]
+[[Category:Pertussis]]
-[[Category:Legionellosis|Legionellosis]]
+[[Category:Legionellosis]]
-[[Category:Yersinia infection|Yersinia infection]]
+[[Category:Yersinia infection]]
-[[Category:Influenza A|Influenza A]]
+[[Category:Influenza A]]

@@ Line 2: / Line 2: @@
    | __TOC__
    |}
-{{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00619 Caspase recruitment domain],<br/>Peptidase C14A family]|[[:Category:Caspase-1|Ligand list]]|Protease}}
+{{#invoke:InfoboxforTarget|run|CASP-1|[https://www.uniprot.org/uniprot/P29466 P29466]|Homo sapiens|Cys285|[http://pfam.xfam.org/family/PF00619 Caspase recruitment domain],<br/>Peptidase C14A family|[[:Category:Caspase-1|Ligand list]]|Protease}}
 ==Summary==