Arginase-1 (Rattus norvegicus) - Revision history

Wu3857: /* Reference */

2019-08-19T21:38:16Z

‎Reference

Wu3857: /* Summary */

2019-08-18T18:24:19Z

‎Summary

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Arg1|[https://www.uniprot.org/uniprot/P07824 P07824]|Rattus norvegicus|Cys119, Cys168, Cys303|[http://pfam.xfam..."

2019-08-18T18:21:41Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Arg1|[https://www.uniprot.org/uniprot/P07824 P07824]|Rattus norvegicus|Cys119, Cys168, Cys303|[http://pfam.xfam..."

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{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|Arg1|[https://www.uniprot.org/uniprot/P07824 P07824]|Rattus norvegicus|Cys119, Cys168, Cys303|[http://pfam.xfam.org/family/PF00491 Arginase family]|[[:Category:Arginase-1 (Rattus norvegicus)|Ligand list]]|Metabolic enzyme}}

==Summary==

===Protein Function ===
Arginase, belongs to the ureohydrolase family of enzymes, which catalyses the conversion of arginine to urea and ornithine, exists as two distinct isoforms (arginase I and arginase II). Arginase I is expressed almost exclusively in the liver where it serves as an essential enzyme of the urea cycle, while arginase II is expressed in the kidney and many other extrahepatic tissues. Arginase catalyzes the fifth and final step in the urea cycle, a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. Specifically, arginase converts L-arginine into L-ornithine and urea. (From Wikipedia, PMID: 18488197) 

===Cys Function & Property===
 

* Hydrophobic property:
:[[File:567-hydro.png||600px]]
* SASA：
:Cys119: 0 A^2 
:Cys168: 15.433 A^2 
:Cys303: 0.158 A^2 

==Protein Sequence==

MSSKPKPIEI IGAPFSKGQP RGGVEKGPAA LRKAGLVEKL KETEYNVRDH 
GDLAFVDVPN DSPFQIVKNP RSVGKANEQL AAVVAETQKN GTISVVLGGD 
HSMAIGSISG HARVHPDL'''C'''V IWVDAHTDIN TPLTTSSGNL HGQPVAFLLK 
ELKGKFPDVP GFSWVTP'''C'''IS AKDIVYIGLR DVDPGEHYII KTLGIKYFSM 
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPVF TPATGTPVVG 
GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTPEEVT RTVNTAVALT 
LS'''C'''FGTKREG NHKPETDYLK PPK 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:[[File:567.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko00220 Arginine biosynthesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko00330 Arginine and proline metabolism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko01100 Metabolic pathways] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko01230 Biosynthesis of amino acids] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko05146 Amoebiasis] 

==Experimental Evidence==
:Homologous Analysis of Sequence, Cys Modification Assay

==Reference==
# Kanda H, Sumi D, Endo A, et al. '''Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism[J].''' Archives of toxicology, 2008, 82(11): 803. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18488197 18488197] 

[[Category:Targets|Targets]]
[[Category:Rattus norvegicus|Rattus norvegicus]]
[[Category:Metabolic enzyme|Metabolic enzyme]]
[[Category:Arginase family|Arginase family]]
[[Category:Arginine biosynthesis|Arginine biosynthesis]]
[[Category:Metabolic pathways|Metabolic pathways]]
[[Category:Arginine and proline metabolism|Arginine and proline metabolism]]
[[Category:Biosynthesis of amino acids|Biosynthesis of amino acids]]
[[Category:Amoebiasis|Amoebiasis]]

@@ Line 49: / Line 49: @@
 # Kanda H, Sumi D, Endo A, et al. '''Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism[J].''' Archives of toxicology, 2008, 82(11): 803. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18488197 18488197]<br/>
-[[Category:Targets|Targets]]
+[[Category:Targets]]
-[[Category:Rattus norvegicus|Rattus norvegicus]]
+[[Category:Rattus norvegicus]]
-[[Category:Metabolic enzyme|Metabolic enzyme]]
+[[Category:Metabolic enzyme]]
-[[Category:Arginase family|Arginase family]]
+[[Category:Arginase family]]
-[[Category:Arginine biosynthesis|Arginine biosynthesis]]
+[[Category:Arginine biosynthesis]]
-[[Category:Metabolic pathways|Metabolic pathways]]
+[[Category:Metabolic pathways]]
-[[Category:Arginine and proline metabolism|Arginine and proline metabolism]]
+[[Category:Arginine and proline metabolism]]
-[[Category:Biosynthesis of amino acids|Biosynthesis of amino acids]]
+[[Category:Biosynthesis of amino acids]]
-[[Category:Amoebiasis|Amoebiasis]]
+[[Category:Amoebiasis]]

@@ Line 10: / Line 10: @@
 ===Cys Function & Property===
 * Hydrophobic property:
@@ Line 18: / Line 17: @@
 :Cys168: 15.433 A^2 <br/>
 :Cys303: 0.158 A^2 <br/>
 ==Protein Sequence==

Arginase-1 (Rattus norvegicus) - Revision history

Wu3857: /* Reference */

Wu3857: /* Summary */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Arg1|[https://www.uniprot.org/uniprot/P07824 P07824]|Rattus norvegicus|Cys119, Cys168, Cys303|[http://pfam.xfam..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|Arg1|[https://www.uniprot.org/uniprot/P07824 P07824]|Rattus norvegicus|Cys119, Cys168, Cys303|[http://pfam.xfam..."