Wu3857: /* Cys Function & Property */

2019-08-22T03:08:05Z

‎Cys Function & Property

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|AR, AKR1B1|[https://www.uniprot.org/uniprot/P15121 P15121]|Homo sapiens|Cys299|[http://pfam.xfam.org/family/PF0..."

2019-08-22T03:06:53Z

Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|AR, AKR1B1|[https://www.uniprot.org/uniprot/P15121 P15121]|Homo sapiens|Cys299|[http://pfam.xfam.org/family/PF0..."

New page

{| align="left"
| __TOC__
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{{#invoke:InfoboxforTarget|run|AR, AKR1B1|[https://www.uniprot.org/uniprot/P15121 P15121]|Homo sapiens|Cys299|[http://pfam.xfam.org/family/PF00248 Aldo/keto reductase family]|[[:Category:Aldo-keto reductase family 1 member B1|Ligand list]]|Metabolic enzyme}}
==Summary==

===Protein Function ===
Aldose reductase is a member of the aldo-keto reductase (AKR) superfamily (AKR1B1). It catalyzes the NADPH-dependent reduction of a broad spectrum of substrates that range from simple aromatic aldehydes and steroid carbonyls to aldo-keto sugars. The wide substrate specificity of AR suggests that the enzyme may be involved in detoxification of endogenous and xenobiotic aldehydes. (PMID: 18223294) 

===Cys Function & Property===
Cys299 is quite clost to the active sites of AKR1B1. 

* Hydrophobic property:
:[[File:582-hydro.png||600px]]
* SASA：
:Cys299: 10.044 A^2 

==Protein Sequence==

MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ 
NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL 
KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD 
EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC 
QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI 
RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRV'''C'''A 
LLSCTSHKDY PFHEEF 


==Structural Information==
*Known structure with covalent ligand: 
:Unknown 

*Protein structure:
:[[File:582.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko00040 Pentose and glucuronate interconversions] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko00051 Fructose and mannose metabolism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko00052 Galactose metabolism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko00561 Glycerolipid metabolism] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko00790 Folate biosynthesis] 
*[https://www.genome.jp/kegg-bin/show_pathway?ko01100 Metabolic pathways] 

==Experimental Evidence==
:Cys-directed Mutation

==Reference==
# Kaiserova K, Tang X L, Srivastava S, et al. '''Role of nitric oxide in regulating aldose reductase activation in the ischemic heart[J].''' Journal of Biological Chemistry, 2008, 283(14): 9101-9112. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18223294 18223294] 

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Metabolic enzyme]]
[[Category:Aldo/keto reductase family]]
[[Category:Pentose and glucuronate interconversions]]
[[Category:Fructose and mannose metabolism]]
[[Category:Galactose metabolism]]
[[Category:Glycerolipid metabolism]]
[[Category:Folate biosynthesis]]
[[Category:Metabolic pathways]]

@@ Line 9: / Line 9: @@
 ===Cys Function & Property===
-Cys299 is quite clost to the active sites of AKR1B1. <br/>
+Cys299 is close to the active sites of AKR1B1 in space, include Trp111, Gln49. <br/>
 * Hydrophobic property:

Aldo-keto reductase family 1 member B1 - Revision history

Wu3857: /* Cys Function & Property */

Wu3857: Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|AR, AKR1B1|[https://www.uniprot.org/uniprot/P15121 P15121]|Homo sapiens|Cys299|[http://pfam.xfam.org/family/PF0..."

Wu3857: Created page with "{| align="left" | TOC |} {{#invoke:InfoboxforTarget|run|AR, AKR1B1|[https://www.uniprot.org/uniprot/P15121 P15121]|Homo sapiens|Cys299|[http://pfam.xfam.org/family/PF0..."